2010 Fiscal Year Final Research Report
Study on the relationship between dermal structure and disposition of tacrolimus in skin after the topical application
| Project/Area Number |
20590152
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Josai University |
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Principal Investigator |
SEKI Toshinobu Josai University, 薬学部, 教授 (60196946)
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| Co-Investigator(Renkei-kenkyūsha) |
EGAWA Yuya 城西大学, 薬学部・薬学科, 助教 (90400267)
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| Project Period (FY) |
2008 – 2010
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| Keywords | タクロリムス / 経皮吸収 / 動物実験代替法 |
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| Research Abstract |
In vitro permeation experiments using excised rat skin and new established skin models consisted of laminated artificial membranes were used to examine disposition of tacrolimus after the topical application. Tacrolimus permeated through the skin via aqueous channel in the damaged skin and the channel was controlled by tight junction structures. Skin components and leaching serum proteins influenced the transfer rate of tacrolimus in skin.
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