2010 Fiscal Year Final Research Report
Development of brain specific drug delivery system with microglia
| Project/Area Number |
20590153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
MAEDA Tomoji Iwate Medical University, 薬学部, 准教授 (60303294)
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| Co-Investigator(Renkei-kenkyūsha) |
KOMANO Hiroto 岩手医科大学, 薬学部, 教授 (40170378)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ミクログリア / ドラッグデリバリーシステム / トランスポーター |
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| Research Abstract |
In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.
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