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2010 Fiscal Year Final Research Report

Development of brain specific drug delivery system with microglia

Research Project

  • PDF
Project/Area Number 20590153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionIwate Medical University

Principal Investigator

MAEDA Tomoji  Iwate Medical University, 薬学部, 准教授 (60303294)

Co-Investigator(Renkei-kenkyūsha) KOMANO Hiroto  岩手医科大学, 薬学部, 教授 (40170378)
Project Period (FY) 2008 – 2010
Keywordsミクログリア / ドラッグデリバリーシステム / トランスポーター
Research Abstract

In this study, we investigated the possibility whether microglia can be used for brain-targeting drug delivery system, since it was reported that microglia is able to enter the brain from blood flow. At first, we studied the effect of nucleotides on the migration of microglia in our assay system. We found that adenosine triphosphate (ATP), thymidine triphosphate (TTP) and cytidine triphosphate (CTP) induced the migration of microglia.

  • Research Products

    (2 results)

All 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer2010

    • Author(s)
      Tomoji Maeda, Masanori Irokawa, Hiroshi Arakawa, Erika Kuraoka, Takashi Nozawa, Ryoko Tateoka, Yoshiharu Itoh, Takeo Nakaishi, Ikumi Tamai
    • Journal Title

      J.Steroid.Biochem.Mol.Biol. 122

      Pages: 180-185

    • Peer Reviewed
  • [Presentation] Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer2010

    • Author(s)
      Takeo Nakaishi, Tomoji Maeda, Masanori Irokawa, Hiroshi Arakawa, Erika Kuraoka, Takashi Nozawa, Ryoko Tateoka, Yoshiharu Itoh, Ikumi Tamai
    • Organizer
      第6回国際ホルモン依存性癌シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-14

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Published: 2012-01-26   Modified: 2016-04-21  

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