2010 Fiscal Year Final Research Report
Regulatory role of ezrin on transportsome at the blood placenta barrier
| Project/Area Number |
20590158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
SAI Yoshimichi Keio University, 附属病院, 准教授 (40262589)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMURA Tomohiro 慶應義塾大学, 薬学部, 助教 (40453518)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
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| Project Period (FY) |
2008 – 2010
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| Keywords | トランスポーター / 生体膜輸送 / 胎盤関門 / 妊娠時薬物療法 |
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| Research Abstract |
This study was aimed to clarify the regulatory role of ezrin on transporter complex (transportsome) at the placenta barrier. Our study using syncytiotrophoblast cell line TR-TBTs, pregnant rats as well as knockout mice lacking ezrin, scaffold protein that links membrane proteins to the cortical actin, have suggested that ezrin is located at the apical membrane of syncytiotrophoblasts during the course of pregnancy and works as a functional regulator in the transportsome containing a hypotaurin transporter Slc6a13.
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[Journal Article] Proton-coupled erythromycin antiport at rat blood-placenta barrier.2010
Author(s)
Sai Y, Nishimura T, Ochi K, Tanaka N, Takagi A, Tomi M, Kose N, Kobayashi Y, Miyakoshi N, Kitagaki S, Mukai C, Nakashima E.
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Journal Title
Drug Metab Dispos 38(9)
Pages: 1576-1581
Peer Reviewed
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[Journal Article] Differential expression of Ezrin and CLP-36 in two layers of syncytiotrophoblast in rats.2010
Author(s)
Higuchi K, Iizasa H, Sai Y, Horieya S, Lee K-E, Wada M, Nishimura T, Wakayama T, Tamura A, Tsukita S, Kose N, Kang Y-S, Nakashima E.
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Journal Title
Biol Pharm Bull 33(8)
Pages: 1400-1406
Peer Reviewed
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[Journal Article] Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT.2008
Author(s)
Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Miyakoshi N, Kang YS, Nakashima E.
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Journal Title
Pharm Res 25(7)
Pages: 1647-1653
Peer Reviewed
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