2010 Fiscal Year Final Research Report
Studies on biosynthesis and metabolism of the glutathione conjugated bile acids
| Project/Area Number |
20590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
MITAMURA Kuniko Kinki University, 薬学部, 准教授 (70242526)
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| Co-Investigator(Kenkyū-buntansha) |
IKEGAWA Shigeo 近畿大学, 薬学部, 教授 (90111301)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 胆汁酸 / グルタチオン / N-アセチルシステイン / エレクトロスプレーイオン化 / 質量分析法 / 胆汁 / プロドラッグ / 硫酸抱合 |
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| Research Abstract |
In order to elucidate the mechanism on the formation and metabolism of glutathione (GSH) conjugated bile acids via their reactive intermediates, we demonstrated that bile acid were tansacylated with GSH and N-acetylcysteine (NAC) by in vitro and in vivo studies. In addition, we clarified that the several kinds of glutathione conjugated bile acids were excreted into the bile of rats and patients with biliary diseases. We also showed the NAC conjugated ursodeoxycholic acid could be a prodrug for hepatobiliary fuction improvement drug.
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[Journal Article] Potential corticoid metabolites : chemical synthesis of 3-and 21-mono-and 3,21-disulfate conjugates of tetrahydrocorticosteroids in the 5α- and 5β series2010
Author(s)
Okihara R, Mitamura K, Hasegawa M, Mori M, Muto A, Kakiyama G, Iida T, Shimada M, Mano N, Ikegawa S
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Journal Title
Chem.Pharm.Bull. 58
Pages: 344-353
Peer Reviewed
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