2010 Fiscal Year Final Research Report
Development of a new evaluation system for generic drugs using taste sensors
| Project/Area Number |
20590166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
UCHIDA Takahiro Mukogawa Women's University, 薬学部, 教授 (70203536)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Miyako 武庫川女子大学, 薬学部, 講師 (20369028)
HAZEKAWA Mai 武庫川女子大学, 薬学部, 助手 (10509186)
HARAGUCHI Tamami 武庫川女子大学, 薬学部, 助手 (10550741)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 苦味強度 / 薬物溶出 / 味覚センサ / 主成分分析 / 官能試験 / 崩壊性 |
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| Research Abstract |
We evaluated the bitterness of dry syrup or orally-disintegrating tablet. Bitterness intensity and dissolved Clarithromycin concentration were well correlated. In the study of Famotidine orally-disintegrating tablet, there was a good correlation between the taste predicted by principal component analysis and the Euclidean distance obtained by the taste sensor, and bitterness intensities obtained in the human gustatory tests. Finally, we evaluated the comprehensive behavior of drugs using a new disintegration testing apparatus in addition to gustatory test and dissolution test.
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