2010 Fiscal Year Final Research Report
Fc receptor-related biological properties of anti-TNF therapeutics
| Project/Area Number |
20590167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
ISHII Akiko National Institute of Health Sciences, 生物薬品部, 第二室長 (50291117)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Takuo 国立医薬品食品衛生研究所, 生物薬品部・第2室, 主任研究官 (10415466)
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部・第2室, 研究員 (50506954)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 抗体医薬品 / Fc融合タンパク質医薬品 / Fc受容体 / FcRn / FcγR / TNF |
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| Research Abstract |
In order to elucidate the differences in the biological activities of anti-TNF therapeutics, their interactions with Fc receptors were examined. TNFR-Fc fusion protein showed lower affinity to FcRn than the anti-TNF antibodies did. Apparent molecular size of the complexes composed of TNF and anti-TNF antibodies differed in each antibody, and the activation of FcγR was dependent on the complex size. These characteristics were thought to be responsible for the differences in their serum half-life regulated by FcRn, and the incidence of infusion reaction or anti-drug antibody, which is related to the activation of FcγR on immune effector cells.
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[Journal Article] Genetic polymorphisms of FCGRT encoding FcRn in a Japanese population and their functional analysis.2010
Author(s)
Ishii-Watabe A, Saito Y, Suzuki T, Tada M, Ukaji M, Maekawa K, Kurose K, Kaniwa N, Sawada J, Kawasaki N, Yamaguchi T, Nakajima TE, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Hamaguchi T, Okuda H, Matsumura Y
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Journal Title
Drug Metab.Pharmacokinet. 25(6)
Pages: 578-587
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