2010 Fiscal Year Final Research Report
Molecular basis for the region specific morphogenesis of the rib depending on the interaction between somites and surface ectoderm.
| Project/Area Number |
20590171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
AOYAMA Hirohiko 広島大学, 大学院・医歯薬学総合研究科, 教授 (70143948)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUI Kouji 広島大学, 大学院・医歯薬学総合研究科, 助教 (80183945)
SAKAMOTO Nobuyuki 広島大学, 大学院・医歯薬学総合研究科, 助教 (90346487)
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| Research Collaborator |
YAMAGUCHI Mami 大阪大学, 大学院・理学研究科, 大学院生
ISABELLA Kurnia liem 広島大学, 大学院・医歯薬学総合研究科, 大学院生
MASUDA Tasuku 広島大学, 大学院・医歯薬学総合研究科, 大学院生
MAEDA Kazutaka 広島大学, 大学院・医歯薬学総合研究科, 大学院生
FAN Haiming 広島大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2010
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| Keywords | 形態形成 / 体節 / 骨格 / 脊椎動物 / ボディプラン / 発生・分化 / 進化 / ニワトリ胚 |
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| Research Abstract |
In the course of evolution, the vertebrae bearing rib localized to form thorax in birds and mammals. The rib is constituted of three developmental compartments. The most distal compartment is the sternal rib, which was not formed when contact between the somites and the lateral plate mesoderm was interrupted in a two-day chick embryo. In this case, the abaxial somitic cells did not appeared. Labeling each somite individually, the 27th somite was shown to form almost entire abdominal muscles as well as the most caudal rib, suggesting that the lumbar somites form neither the ribs nor the body wall muscles. To understand molecular entity of the interaction between surface ectoderm and somites in the distal rib-genesis, Wnt6 and Fzd7 were cloned.
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[Journal Article] Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice. Invest.2009
Author(s)
Sasaki, T., Watanabe, W., Muranishi, Y., Kanamoto, T., Aihara, M., Miyazaki, K., Tamura, H., Saeki, T., Oda, H., Souchelnytskyi, N., Souchelnytskyi, S., Aoyama, H., Honda, Z., Furukawa, T., Mishima, H. K., Kiuchi, Y., Honda, H.
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Journal Title
Ophthalmol. Vis. Sci
Volume: 50
Pages: 242-248
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