2010 Fiscal Year Final Research Report
Trial to identify membranous protein(s) regulating the planar cell polarity
| Project/Area Number |
20590172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Ehime University |
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Principal Investigator |
KOBAYASHI Naoto Ehime University, 大学院・医学系研究科, 教授 (50234836)
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| Co-Investigator(Kenkyū-buntansha) |
HAMADA Fumihiko 大分大学, 医学部, 教授 (70252707)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 発生・分化 / 平面内細胞極性 / 平面内細胞極性形成シグナル伝達 / Frizzled受容体 / Frizzledリガンド / ショウジョウバエS2細胞株 / キメラ受容体分子 |
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| Research Abstract |
Planar cell polarity is known to be established mainly by the signals originated from the Frizzled-1 receptor localized on the plasma membrane, although available information on the ligand molecule for Frizzled-1 is still limited. The present study has aimed to reveal the unknown ligand molecule(s) using Drosophila cell culture system coupled with chimeric molecule (Frizzled-1-Frizzled-2 chimeras) technique. We have established culture cell-based assay system of the target molecules, together with the constructs enabling to express various membranous receptor molecules reported in Drosophila. We are trying to survey receptor molecules to reveal the Frizzled-1-ligand in question.
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Research Products
(11 results)
