2010 Fiscal Year Final Research Report
Developments of cerebral sulci and gyri in cynomolgus monkey fetuses : a quantitative analysis using 7 tesla MRI
| Project/Area Number |
20590176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tsukuba International University |
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Principal Investigator |
澤田 和彦 Tsukuba International University, 医療保健学部, 教授 (10284324)
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| Co-Investigator(Kenkyū-buntansha) |
坂田 ひろみ 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (50294666)
孫 学智 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員 (00284323)
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| Project Period (FY) |
2008 – 2010
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| Keywords | サル / 大脳 / 脳溝 / 脳回 / MRI胎 / 仔 / 霊長類 / 系統発生 |
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| Research Abstract |
T1-weighted MRI images were acquired from formalin-fixed cerebra of cynomolgus monkey fetuses on embryonic days (EDs) 70 to 150 using a high spatial resolution 7-tesla MR system. The results clarified MRI-based chronology of the emergences of cerebral sulci and gyri in this primate. Quantitative analysis revealed a correlation of the emergence of the primary sulci with the development of subcortical white matter bundles. Furthermore, diffusion tensor imaging revealed a spatiotemporal relation of each primary sulci with the specific cortico-cortical long associative fibers.
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