2011 Fiscal Year Final Research Report
The role of Sox17 during mouse early endoderm to its delivertives
| Project/Area Number |
20590178
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Tokyo Medical and Dental University (2010-2011)
Kyorin University (2008-2009) |
|---|
Principal Investigator |
KANAI Masami 東京医科歯科大学, 実験動物センター, 教授 (70321883)
|
|---|
| Project Period (FY) |
2008 – 2011
|
| Keywords | 内胚葉 / 発生・分化 / ノックアウトマウス / 腸管形成 / 肝臓 / 胆のう |
|---|
| Research Abstract |
The definitive gut endoderm give rise to various cell-types constituting digestive tract, liver, pancreas and associated visceral endoderm. In order to examine primordium endoderm(9. 5 dpc) development, we have cultured them for 3 days, and then analyzed the development/maturation in each explant. We have examined that chimeric study between Sox17 null ES cells introducing to wild blastcyst and their DNA array. Our observation strongly indicate that a critical role of Sox17 in the determination of the cell into the endoderm and its derivative organ in mammals. These findings lead us to the possibility that Sox17is one of the key genes for the isolation of the endodermal stem cells and obtaining of the endodermal cells derived from ES cells in the human therapeutic research for the future.
|
Research Products
(35 results)
