2010 Fiscal Year Final Research Report
Exploratory research on regulating factors for intracellular dynamics of neuronal cytoskeleton
| Project/Area Number |
20590185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TERADA Sumio Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00262022)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGSHI Masahiko 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60323606)
HOSHINO Mitsunobu 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60431962)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 細胞骨格蛋白質 / 神経 / 分子細胞生物学 / 調節因子 |
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| Research Abstract |
We have established the screening system to identify the regulating factors for intracellular dynamics of neuronal cytoskeleton. By using gene tip and chemical screening system, we have identified several candidate factors or chemicals, and more detailed characterization is under way. We also reported that a chaperone molecule Hsc70 plays a role as a scaffolding factor during intracellular transport dynamics in neurons.
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