2010 Fiscal Year Final Research Report
Dynamic analysis of selective microRNA transport and its application to pathological diagnosis
| Project/Area Number |
20590200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nippon Medical School |
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Principal Investigator |
ISHIBASHI Osamu Nippon Medical School, 医学部, 講師 (70293214)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Toshihiro 日本医科大学, 大学院・医学研究科, 教授 (90271220)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 機能解剖学 |
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| Research Abstract |
MicroRNAs (miRNAs) are small RNAs that play a role in post-transcriptional regulation of gene expression. miRNAs are also secreted extracellularly via exosomes and can be detected in body fluids including blood; thus they could be promising biomarkers for various diseases. However, the intracellular dynamics, including a pathway prior to extracellular release, of miRNAs is not well understood. In this study, we performed bio-imaging analyses to examine intracellular dynamics of miRNAs and miRNA-associated proteins. Further, we performed the profiling analysis of miRNAs that are extracellularly secreted via exosomes to characterize them.
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Research Products
(9 results)
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[Journal Article] Human villous trophoblasts express and secrete placenta-specific micrornas into maternal circulation via exosomes.2009
Author(s)
Luo S.S., Ishibashi O., Ishikawa G., Ishikawa T., Katayama A., Mishima T., Takizawa T., Shigihara T., Goto T., Izumi A., Ohkuchi A., Matsubara S., Takeshita T., Takizawa T.
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Journal Title
Biol Reprod. 81
Pages: 717-729
Peer Reviewed
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