Improvement of exercise performance by gene therapy

2010 Fiscal Year Self-evaluation Report

• Project/Area Number: 20590215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Kio University
• Principal Investigator: SAKATA Susumu Kio University, 健康科学部, 教授 (20142383)
• Project Period (FY): 2008 – 2011
• Keywords: 遺伝子治療 / SERCA2a / 不全心 / 再生医学 / 運動生理学 / ラット / 運動パフォーマンス

Research Abstract

大動脈弓狭窄誘発性心不全モデルラットの心臓は左室肥厚性肥大心であり、筋小胞体カルシウムポンプ(SERCA2a)のmRNAおよび蛋白の発現は低下している。これが主原因で左室の収縮/拡張不全を引き起こすことが知られている。本研究は、この心不全モデルラットの心臓にSERCA2a遺伝子をin vivo導入することで、不全心の心機能を改善させると同時に、不全心ラットの運動パフォーマンスが、健常レベルに回復するかどうか、について明らかにすることを目的とする。

Research Products

• [Journal Article] Development of a preclinical model of ischemic cardiomyopathy in swine. (2011)
  • Author(s): Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ, Kawase Y
  • Journal Title: Am J Physiol Heart & Circ Physiol
  • URL: Doi:10.1152/ajpheart:01103.2010
  • Peer Reviewed
• [Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a (2009)
  • Author(s): Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ, Lebeche D
  • Journal Title: PLoS ONE 4(7) Pages: 6474
  • URL: doi:10.1371/journal.pone.0006474
  • Peer Reviewed
• [Presentation] Voluntary wheel running decreases blood pressure and increases endurance capacity in rats. (2011)
  • Author(s): Sakata S, Nishii Y, Hanaoka T, Ishizawa R, Iwami K, Minematsu A, Imagita H, Itou A, Waki H, Nakatani A
  • Organizer: The Joint Meeting of The 88th Annual Meeting of the Physiological Society of Japan and The 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Japan
  • Year and Date: 20110300
• [Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure. (2010)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M, Hajjar RJ
  • Organizer: 20th World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100500
• [Presentation] Dynamic changes in left ventricular mechanoenergetics during development of cardiac hypertrophy and failure. (2009)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Chemaly ER, Takaki M, Hajjar RJ
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090700-20090800
• [Remarks] ホームページ
  • URL: http://www.kio.ac.jp/