Improvement of exercise performance by gene therapy

2011 Fiscal Year Final Research Report

• Project/Area Number: 20590215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General physiology
• Research Institution: Kio University
• Principal Investigator: SAKATA Susumu 畿央大学, 健康科学部, 教授 (20142383)
• Co-Investigator(Kenkyū-buntansha): NAKATANI Akira 奈良教育大学, 教育学部, 教授 (70116284) ; TAKAKI Miyako 奈良県立医科大学, 医学部, 教授 (00033358)
• Project Period (FY): 2008 – 2011
• Keywords: 遺伝子治療 / SERCA2a / 不全心 / 再生医学 / 運動生理学 / ラット / 運動パフォーマンス

Research Abstract

Systolic/diastolic blood pressures(BP) in aortic-banding(Band) group were lower than those in sham-operation(Sham) group 6-18 months after the operation. Likewise, endurance capacity was lower in"Band"than in"Sham"18 months after the operation. However, systolic BP and endurance capacity in"Band"could be increased by 3 week-voluntary wheel-running exercise. To conclude, these results suggest that daily light exercise is a potential strategy for improving BP and endurance capacity in patients with heart failure.

Research Products

• [Journal Article] Development of a pre-clinical model of ischemic cardiomyopathy in swine (2011)
  • Author(s): Ishikawa K, Ladage D, Takewa Y, Yaniz E, Chen J, Tilemann L, Sakata S, Badimon JJ, Hajjar RJ & Kawase Y
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 301 Pages: H530-H537
  • DOI: Doi:10.1152/ajpheart.01103.2010.
  • Peer Reviewed
• [Journal Article] Gene remodeling in type 2 diabetic cardiomyopathy and its phenotypic rescue with SERCA2a (2009)
  • Author(s): Karakikes I, Kim M, Hadri L, Sakata S, Sun Y, Zhang W, Chemaly ER, Hajjar RJ & Lebeche D
  • Journal Title: PLoS ONE Volume: 4(7) Pages: e6474
  • DOI: doi:10.1371/journal.pone.0006474.
  • Peer Reviewed
• [Journal Article] Role of resistin in cardiac contractility and hypertrophy (2008)
  • Author(s): Kim M, Oh JK, Sakata S, Liang LF, Park WJ, Hajjar RJ & Lebeche D
  • Journal Title: J Mol & Cell Cardiol Volume: 45 Pages: 270-280
  • DOI: doi:10.1016/j.yjmcc.2008.05.006.
  • Peer Reviewed
• [Journal Article] Reversal of cardiac dysfunction following long term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure (2008)
  • Author(s): Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H, Hadri L, Yoneyama R, Hoshino K, Takewa Y, Sakata S, Peluso R, Zsebo K, Gwathmey JK, Tardif J-C, Tanguay J-F & Hajjar RJ
  • Journal Title: J Am Coll Cardiol Volume: 51 Pages: 1112-1119
  • DOI: doi:10.1016/j.jacc.2007.12.014.
  • Peer Reviewed
• [Presentation] Voluntary wheel-running lowers blood pressure and elevates endurance capacity in rats (2011)
  • Author(s): Nishii Y, Hanaoka T, Iwami K, Imagita H, Minematsu A, Waki H, Nakatani A, Kaneko A & Sakata S
  • Organizer: The 7th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20110900
• [Presentation] Effects of different high fat diets on FABP content in rat skeletal muscles (2011)
  • Author(s): Ishizawa R, Sakata S & Nakatani A
  • Organizer: 58th Annual Meeting of American College of Sports Medicine
  • Place of Presentation: Denver, USA
  • Year and Date: 20110600
• [Presentation] Assessing myocardial systolic function : are we moving beyond the end-systolic elastance of the left ventricle (2011)
  • Author(s): Chemaly ER, Chaanine A, Sakata S & Hajjar RJ
  • Organizer: 2011 North American Section Meeting International Society for Heart Research
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 20110500
• [Presentation] Voluntary wheel running decreases blood pressure and increases endurance capacity in rats (2011)
  • Author(s): Sakata S, Nishii Y, Hanaoka T, Ishizawa R, Iwami K, Minematsu A, Imagita H, Itou A, Waki H & Nakatani A
  • Organizer: The Joint Meeting of The 88th Annual Meeting of the Physiological Society of Japan and The 116th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Japan
  • Year and Date: 20110300
• [Presentation] Left ventricular mechanoenergetics during development of cardiac hypertrophy and failure (2010)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Nishii Y, Chemaly ER, Kawase Y, Takaki M & Hajjar RJ
  • Organizer: 20th World Congress of the International Society for Heart Research
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100500
• [Presentation] Dynamic changes in left ventricular mechanoenergetics during development of cardiac hypertrophy and failure (2009)
  • Author(s): Sakata S, Sakata N, Sakata Y, Lebeche D, Hanaoka T, Chemaly ER, Takaki M & Hajjar RJ
  • Organizer: 36th International Congress of Physiological Sciences
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-08
• [Remarks]
  • URL: http://www.kio.ac.jp/