2010 Fiscal Year Final Research Report
Analysis of the neuronal network that generates respiratory rhythm and pattern
| Project/Area Number |
20590218
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
OKADA Yasumasa Keio University, 医学部, 准教授 (80160688)
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| Co-Investigator(Kenkyū-buntansha) |
OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512)
MIWAKEICHI Fumikazu 統計数理研究所, モデリング研究系, 准教授 (30360647)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 呼吸調節 / 膜電位イメージング / 高位頚髄呼吸神経細胞群 / 呼吸リズム / 呼吸パターン形成 / 横隔神経核 / 横隔膜 / 斜角筋 |
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| Research Abstract |
To elucidate the function and anatomy of the respiratory neuron groups in the cervical spinal cord that are involved in respiratory rhythm and pattern generation, we conducted voltage imaging, electrophysiological recording and immunohistological analyses in in vitro and in situ rat preparations. We found a novel respiratory neuron group in the high (C1-C2) cervical spinal cord, and reported it as "High Cervical Spinal Cord Respiratory Neuron Group (HCRG)". We also analyzed the spatiotemporal profiles of the respiratory neurons at the level of the phrenic nucleus (C3-C5 level), and found that phrenic and scalene motoneurons are located at the same level but separately with distinct activity patterns. These findings will be the basis to better understand the pathophysiology of respiratory disturbance accompanied with cervical spinal cord injury and to develop new treatment modality.
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[Journal Article] Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn2011
Author(s)
Ryoma Aoyama, Yasumasa Okada, Shigefumi Yokota, Yutaka Yasui, Kentaro Fukuda, Yoshio Shinozaki, Hideaki Yoshida, Masaya Nakamura, Kazuhiro Chiba, Yukihiko Yasui, Fusao Kato, Yoshiaki Toyama
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Journal Title
Peer Reviewed
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