2010 Fiscal Year Final Research Report
New synthetic peptide enhances plasminogen activation and thrombolysis
| Project/Area Number |
20590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
OKADA Kiyotaka Kinki University, 医学部, 講師 (20185432)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Osamu 近畿大学, 医学部, 教授 (40030879)
KAWAO Naoyuki 近畿大学, 医学部, 助教 (70388510)
UESHIMA Shigeru 近畿大学, 農学部, 教授 (30193791)
NAGAI Nobuo 長浜バイオ大学, バイオサイエンス学部, 教授 (90260281)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血液凝固 / 血液レオロジー |
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| Research Abstract |
A new synthetic nonadecapeptide (SP) corresponding to Glu22-Leu40 of staphylokinase molecule bound to plasminogen (Plg) and enhanced the activation of Plg by Plg activator (PA). This binding was completely inhibited by synthetic peptide corresponding to C-terminal region of plasmin B-chain. SP binds to Glu-Plg, and induces structural changes of Glu-Plg. When SP was administrated in mouse thrombosis model, earlier recanalization was observed than in mice with vehicle administration. Thus, SP enhanced Plg activation and induced effective thrombolysis.
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Research Products
(11 results)
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[Journal Article] Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.2011
Author(s)
Kanno Y, Ishisaki A, Kawashita E, Chosa, N, Nakajima K, Nishihara T, Toyoshima K, Okada K, Ueshima S, Matsushita K, Matsuo O, Matsuno H
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Journal Title
Peer Reviewed
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[Journal Article] Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.2011
Author(s)
Taniguchi Y, Inoue N, Morita S, Nikaido Y, Nakashima T, Nagai N, Okada K, Matsuo O, Miyata S
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Journal Title
Cell Tissue Res 343
Pages: 303-317
Peer Reviewed
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