2010 Fiscal Year Final Research Report
Driving force of paracellular transport and its control by intracellular signals.
| Project/Area Number |
20590225
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
MURAKAMI Masataka National Institute for Physiological Sciences, 細胞器官研究系, 准教授 (10104275)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIYA Hiroshi 日本大学, 生物資源学部, 教授 (20050114)
HASHIMOTO Sadamitsu 東京歯科大学, 歯学部, 准教授 (10201708)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 唾液腺 / タイト結合 / 傍細胞輸送 / 血管灌流 / 水輸送 / 細胞内信号 / 蛍光物質分泌 / 駆動力 |
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| Research Abstract |
The isolated and vascularly perfused mandibular gland of rat was used to assess driving force of paracellular water/solute transport and its control by intracellular signals. The intracellular cAMP-increasing stimulant opens tight junction and induces small paracellular fluid secretion by increasing perfusion pressure. The intracellular Ca-increasing stimulant also opens the tight junction and induced a massive paracellular water/solute transport by perfusion pressure and additional unknown driving force.
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