2010 Fiscal Year Final Research Report
Mechanisms of inhibitory effects of estrogens on psychological stress-induced pressor response via suppression of oxidative stress
| Project/Area Number |
20590230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nara Women's University |
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Principal Investigator |
MORIMOTO Keiko Nara Women's University, 生活環境学部, 教授 (30220081)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMATA Akira 奈良女子大学, 生活環境学部, 教授 (00264755)
UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875)
KIMURA Hiroko 順天堂大学, 医学部, 准教授 (00053299)
YOSHIDA KenーIchi 東京大学, 大学院・医学系研究科, 教授 (40166947)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 精神性ストレス / エストロゲン / 閉経後女性 / 閉経モデルラット / 酸化ストレス / 血圧調節 / 血管収縮反応 / 一酸化窒素 |
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| Research Abstract |
The findings of experiments with volunteers or ovariectomized rats suggested that the menopause enhanced forearm vascular resistance to mental stress, and estrogen replacement attenuated pressor responses through its anti-oxidative activity.
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