Effect of green odor on physiological responses to mental stress in humans

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590231
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Shimane University
• Principal Investigator: SHIDO Osamu Shimane University, 医学部, 教授 (40175386)
• Co-Investigator(Kenkyū-buntansha): MATSUZAKI Kentaro 島根大学, 医学部, 助教 (90457185) ; KATAKURA Masanori 島根大学, 医学部, 助教 (40383179) ; HASHIMOTO Michio 島根大学, 医学部, 准教授 (70112133)
• Project Period (FY): 2008 – 2010
• Keywords: みどりの香り / (Z)-3-hexenol / (E)-2-hexenal / ACTH / 体温調節 / Stroop Color-Word Test / 指先血流量 / 隔離ストレス / 精神ストレス / 医療現場

Research Abstract

We investigated the influence of green odor (a mixture of equal amounts of (Z)-3-hexenol and (E)-2-hexenal diluted to 0.03% (w/w)) administration on various physiological responses to two types of mild mental stress in human subjects. Stroop Color-Word Test significantly reduced finger blood flow and cutaneous temperature, and raised palmer sweating rate. These responses were clearly attenuated by green odor inhalation. In addition, green odor tended to depress plasma ACTH level after the mental stress. During 24-h isolation in a hospital room, green odor spray significantly lowered rectal temperature of subjects only during sleeping time. At the end of isolation, plasma glucose level was significantly elevated by green odor treatments. These results suggest a good possibility that green odor inhalation may attenuate physiological responses to acute mild mental stress in humans.

Research Products

• [Journal Article] Proliferation of neuronal progenitor cells and neuronal diggerentiation in the hypothalamus are enhanced in heat-acclimated rats. (2009)
  • Author(s): Kentaro Matsuzaki, Masanori Katakura, Toshiko Hara, Guanghua Li, Michio Hashimoto, Osamu Shido
  • Journal Title: Pfugers Arch-Eur J Physiol Vol.458 Pages: 661-673
  • Peer Reviewed
• [Journal Article] Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. (2009)
  • Author(s): Katakura M, Hashimoto M, H.M.Shahdat, S.Gamoh, T Okui, Kentaro Matsuzaki, Shido O
  • Journal Title: Neuroscience Vol.160 Pages: 651-660
  • Peer Reviewed
• [Journal Article] Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells. (2009)
  • Author(s): M.Katakura, M.Hashimoto, H.M. Shahdat, S.Gamoh, T.Okui, K.Matsuzaki, O.Shido
  • Journal Title: Neuroscience 160(3) Pages: 651-660
  • Peer Reviewed
• [Journal Article] Long-term administration of green tea catechins increases antioxidative actions and enhances neurogenesis in the hippocampus of rats. (2009)
  • Author(s): Himi, M.Hashimoto, M.Katakura, A.M.Haque, Y.Hara, O.Shido
  • Journal Title: Cur Top Nutraceutical Res 7(3/4) Pages: 131-140
  • Peer Reviewed
• [Journal Article] Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated rats. (2009)
  • Author(s): K.Matsuzaki, M.Katakura, T.Hara, G.Li, M.Hashimoto, O.Shido.
  • Journal Title: Pflugers Arch 458(4) Pages: 661-673
  • Peer Reviewed
• [Journal Article] Mechanism of docosahexaenoic acid- induced inhibition of in vitro Aβ_(1-42) fibrillation and Aβ_(1-42)-induced toxicity in SH-SY5Y cells. (2009)
  • Author(s): S.Hossain, M.Hashimoto, M.Katakura, K.Miwa, T.Shimada, O.Shido
  • Journal Title: J Neurochem 111(2) Pages: 568-579
  • Peer Reviewed
• [Journal Article] Effects of docosahexaenoic acid on in vitro amyloid βpeptide 25-35 fibrillation. (2009)
  • Author(s): M.Hashimoto, H.M.Shahdat, M.Katakura, Y.Tanabe, S.Gamoh, K.Miwa, T.Shimada, O.Shido
  • Journal Title: Biochim Biophys Acta 1791(4) Pages: 289-296
  • Peer Reviewed
• [Journal Article] Effects of redecoration of a hospital isolation room with natural materials on stress levels of denizens in cold season (2008)
  • Author(s): Hiromi Ohta, Megumi Maruyama, Yoko Tanabe, Toshiko Hara, Yoshihiko Nishino, Yoshio Tsujino, Eishin Morita, Shotai Kobayashi, Osamu Shido
  • Journal Title: Int J Biometeorol Vol.52 Pages: 331-340
  • Peer Reviewed
• [Presentation] Anapyrexia in endotherm (2011)
  • Author(s): Shido Osamu, Matsuzaki Kentaro, Katakura Masanori, Tanabe Yoko, Hara Toshiko
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-03-28
• [Presentation] Neuronal phenotype and localization of heat exposure-generated newborn neurons in the hypothalamus of rats. (2011)
  • Author(s): Matsuzaki Kentaro, Katakura Masanori, Hara Toshiko, Li Guanghua, Hashimoto Michio, Shido Osamu
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-03-28
• [Presentation] Mechanism of docosahexaenoic acid-induced inhibition of in vitro amyloid β-induced fibrillation and toxicity in neuronal cells. (2011)
  • Author(s): Hashimoto Michio, Shahdat Hosssain, Katakura Masanori, Shido Osamu
  • Organizer: 第88回日本生理学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-03-28
• [Presentation] Effects of polyunsaturated fatty acids on the cell cycle and the expression of bHLH transcription factors in neural stem cells. (2010)
  • Author(s): Katakura M, Hashimoto M, Okui T, Shido O
  • Organizer: 9th Congress of the International Society for the Study of Fatty Acids & Lipis incorporating the 8th international congress on Essential Fatty Acids and Eicosanoids and the 5th PUFA in Maternal and infant Health meeting.
  • Place of Presentation: Maastricht, The Netherlands
  • Year and Date: 20100529-20100602
• [Presentation] Anapyrexia in endotherm. (2010)
  • Author(s): Osamu Shido, Kentaro Matsuzaki, Masanori Katakura, Yoko Tanabe, Toshiko Hara
  • Organizer: The 87th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: Morioka, Iwate
  • Year and Date: 20100500
• [Presentation] Neuronal phenotype and localization of heat exposure-generated newborn neurons in the hypothalamus of rats. (2010)
  • Author(s): Kentaro Matsuzaki, Masanori Katakura, Toshiko Hara, Guanghua Li, Michio Hashimoto, Osamu Shido
  • Organizer: The 87th Annual Meeting of the Physiological Society of Japan.
  • Place of Presentation: Morioka, Iwate
  • Year and Date: 20100500
• [Presentation] Green tea catechins prevet memory impairment in Alzheimer's diseases model rats by decreasing amyloid βlevels and oxidative stress in cerebral cortex. (2010)
  • Author(s): Abdul Haque, Michio Hashimoto, Kentaro Matsuzaki, Osamu Shido
  • Organizer: 第62回日本生理学会中国四国地方会
  • Place of Presentation: 出雲
  • Year and Date: 2010-11-21
• [Presentation] 長期暑熱馴化形成時に視床下部で新生した神経細胞の機能性解析 (2010)
  • Author(s): 松崎健太郎, 片倉賢紀、井上隆之、Abdul Haque, 原俊子, 橋本道男、紫藤治
  • Organizer: 第62回日本生理学会中国四国地方会
  • Place of Presentation: 出雲
  • Year and Date: 2010-11-21
• [Presentation] "みどりの香り"が精神的ストレスに対する生理的応答へ及ぼす影響 (2010)
  • Author(s): 吉岡みち子, 松崎健太郎, 田邊洋子, 片倉賢紀、原俊子, 紫藤治
  • Organizer: 第49回日本生気象学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-06
• [Presentation] 暑熱曝露によるラット視床下部神経新生と暑熱馴化形成の加齢変化 (2010)
  • Author(s): 松崎健太郎, 片倉賢紀、原俊子, 紫藤治
  • Organizer: 第49回日本生気象学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-06
• [Presentation] 暑熱馴化によるラット唾液分泌促進の分子メカニズム (2010)
  • Author(s): 松崎健太郎、杉本直俊、片倉賢紀、原俊子、橋本道男、紫藤治
  • Organizer: 平成22年度生理研研究会「温熱生理研究会」
  • Place of Presentation: 岡崎
  • Year and Date: 2010-09-09
• [Presentation] 暑熱曝露によるラット視床下部神経新生の加齢による変化 (2009)
  • Author(s): 松崎健太郎, 片倉賢紀, 原俊子, 李光華, 紫藤治
  • Organizer: 第48回日本生気象学会大会
  • Place of Presentation: つくば市
  • Year and Date: 20091123-20091124
• [Presentation] ラット視床下部における暑熱曝露による神経新生の加齢変化 (2009)
  • Author(s): 松崎健太郎, 片倉賢紀, 原俊子, 李光華, 橋本道男, 紫藤治
  • Organizer: 第61回日本生理学会中国四国地方会
  • Place of Presentation: 宇部市
  • Year and Date: 20091100
• [Presentation] 「省エネ型体温調節」暑熱馴化の意義-個体レベルと社会レベルの観点から (2009)
  • Author(s): 紫藤治, 松崎健太郎, 片倉賢紀, 丸山めぐみ, 李光華
  • Organizer: 平成21年度体温調節、温度受容研究会
  • Place of Presentation: 岡崎市
  • Year and Date: 20090900
• [Presentation] Possible central mechanism of long-term heat acclimation. (2009)
  • Author(s): 松崎健太郎
  • Organizer: The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation.
  • Place of Presentation: 松江
  • Year and Date: 20090723-20090726
• [Presentation] Modification of proliferation and defferentiation of hypothalamus progenitor cells by exercise in adult rats. (2009)
  • Author(s): Li G, Matsuzaki K, Katakura M, Hara T, Shido O
  • Organizer: The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation.
  • Place of Presentation: 松江
  • Year and Date: 20090723-20090726
• [Presentation] 脳底動脈における血管収縮物質による収縮後・弛緩反応はEDHF が介在する (2009)
  • Author(s): Enkhjaragal Budbazar, 橋本道男, 坂井泰, 紫藤治
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 20090316-20090318
• [Presentation] Docosahexaenoic acid attenuates in vitro AB fibrillation with concomitant decreases of AB peptide levels in brain of AD model rats. (2009)
  • Author(s): M Hashimoto, S.Hossain, M Katakura, Y Tanabe, S Gamoh, O Shido
  • Organizer: 9^<th> International Conference AD/PD 2009.
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 20090311-20090315
• [Presentation] The protective effects of prescription omega-3 Ffatty acids on the impairment of spatial cognition learning ability in amyloid β-infused rats. (2009)
  • Author(s): S.Nishimoto, Hashimoto M, R.Tozawa, M.Katakura, S.Hossain, A.Haque, O.Shido
  • Organizer: 9^<th> International Conference AD/PD 2009.
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 20090311-20090315
• [Presentation] Effect of polyunsaturated fatty acids on the cell cycle and the expression of bHLT transcriptional factors in niural trem cells. (2009)
  • Author(s): Masanori Katakura, Michio Hashimoto, Shuji Gamoh, Toshiyuki Okui, Kentaro Matsuzaki, Osamu Shido
  • Organizer: The 36th congress of the international Union of Physiological Sciences.
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-27
• [Presentation] 運動トレーニングによる視床下部神経前駆細胞の分裂と分化 (2008)
  • Author(s): 李光華、松崎健太郎、片倉賢紀、原俊子、紫藤治
  • Organizer: 第47回日本生気象学会大会
  • Place of Presentation: 奈良
  • Year and Date: 20081123-20081124
• [Presentation] ラット暑熱馴化の成立に視床下部神経前駆細胞の分裂と分化が関与する可能性 (2008)
  • Author(s): 松崎健太郎、片倉賢紀、丸山めぐみ、原俊子、橋本道男、紫藤治
  • Organizer: 平成20年度生理研研究会「体温調節、温度受容研究会」
  • Place of Presentation: 岡崎
  • Year and Date: 20080918-20080919
• [Presentation] ドコサヘキサエン酸による神経幹細胞のbHLH転写因子の発現量と細胞周期の変化 (2008)
  • Author(s): 片倉賢紀、橋本道男、松崎健太郎、紫藤治
  • Organizer: 第60回日本生理学会中国四国地方会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-11-15
• [Book] からだの温度の事典(B.臨床医学(編集)) (2010)
  • Author(s): 紫藤治, 他
  • Total Pages: 86-168
  • Publisher: 朝倉書店、東京
• [Remarks] ホームページ等