Roles of the PrRP-oxytocin pathway in the control of stress and social behaviour

2010 Fiscal Year Final Research Report

• Project/Area Number: 20590237
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: ONAKA Tatsushi Jichi Medical University, 医学部, 教授 (90177254)
• Co-Investigator(Renkei-kenkyūsha): TAKAYANAGI Yuki 自治医科大学, 医学部, 助教 (10418890)
• Project Period (FY): 2008 – 2010
• Keywords: オキシトン / PrRP / 不安行動 / 社会記憶 / セロトニン / バゾプレシ

Research Abstract

Not only stressful stimuli but also food intake activated PrRP-synthesizing neurons and oxytocin-synthesizing neurons. Social stimuli activated oxytocin-synthesizing neurons. PrRP-synthesizing neurons were suggested to have stress-modulating and anorexic actions. Oxytocin-synthesizing neurons were suggested to have anti-stress, anorexic and social memory-enhancing actions. Downstream neurons of oxytocin-synthesizing neurons were suggested to be serotoninergic.

Research Products

• [Journal Article] Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats. (2011)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Journal Title: J Neuroendocrinol 23(1) Pages: 20-27
  • Peer Reviewed
• [Journal Article] An intrinsic vasopressin system in the olfactory bulb is involved in social recognition. (2010)
  • Author(s): Tobin VA, Hashimoto H, Wacker DW, Takayanagi Y, Langnaese K, Caquineau C, Noack J, Landgraf R, Onaka T, Leng G, Meddle SL, Engelmann M, Ludwig M
  • Journal Title: Nature 464(7287) Pages: 413-417
  • Peer Reviewed
• [Journal Article] Participation of the prolactin-releasing peptide-containing neurons in caudal medulla in conveying hemorrhagic stress-induced signals to the paraventricular nucleus of the hypothalamus. (2010)
  • Author(s): Uchida K, Kobayashi D, Das G, Onaka T, Inoue K, Itoi K
  • Journal Title: J Neuroendocrinol 22(1) Pages: 33-42
  • Peer Reviewed
• [Journal Article] Roles of prolactin-releasing peptide and RFamide related peptides in the control of stress and food intake. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Journal Title: FEBS J 277(24) Pages: 4998-5005
  • Peer Reviewed
• [Journal Article] Metabolic and stress-related roles of prolactin-releasing peptide. (2010)
  • Author(s): Onaka T, Takayanagi Y, Leng G
  • Journal Title: Trends Endocrinol Metab 21(5) Pages: 287-293
  • Peer Reviewed
• [Journal Article] Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. (2009)
  • Author(s): Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young L, Onaka T, Nishimori K
  • Journal Title: J Neurosci 29(7) Pages: 2259-2271
  • Peer Reviewed
• [Journal Article] Dog's gaze at its owner increases owner's urinary oxytocin during social interaction. (2009)
  • Author(s): Nagasawa M, Kikusui T, Onaka T, Ohta M
  • Journal Title: Horm Behav 55(3) Pages: 434-441
  • Peer Reviewed
• [Journal Article] Endogenous prolactin-releasing peptide regulates food intake in rodents. (2008)
  • Author(s): Takayanagi Y, Matsumoto H, Nakata M, Mera T, Fukusumi S, Hinuma S, Ueta Y, Yada T, Leng G, Onaka T
  • Journal Title: J Clinical Invest 118(12) Pages: 4014-4024
  • Peer Reviewed
• [Journal Article] Oxytocin receptor-deficient mice developed late-onset obesity. (2008)
  • Author(s): Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K
  • Journal Title: NeuroReport 19(9) Pages: 951-955
  • Peer Reviewed
• [Journal Article] Oxytocin and appetite. (2008)
  • Author(s): Leng G, Onaka T, Caquineau C, Sabatier N, Tobin VA, Takayanagi Y
  • Journal Title: Prog Brain Res. 170 Pages: 137-151
• [Presentation] Secretin facilitates social behaviors via activation of oxytocin receptors. (2010)
  • Author(s): Takayanagi Y, Takashima A, Onaka T
  • Organizer: The 33^<rd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe
  • Year and Date: 20100902-20100904
• [Presentation] Effects of Rfamide related peptides upon oxytocin release in rats. (2010)
  • Author(s): Takayanagi Y, Kaewwongse M, Onaka T
  • Organizer: The 7^<th> International Congress Neuroendocrinology (ICN2010)
  • Place of Presentation: Rouen, France
  • Year and Date: 2010-07-14
• [Presentation] Neurohypophyseal hormones and stress responses or social behavior : analysis with the use of specific destruction of vasopressin neurons. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka
  • Year and Date: 2010-05-20
• [Presentation] Roles of secretin and oxytocin in social recognition in mice. (2010)
  • Author(s): Takashima A, Takayanagi Y, Saito M, Yamagata T, Momoi M, Onaka T
  • Organizer: The 87^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Morioka
  • Year and Date: 2010-05-20
• [Presentation] Roles of vasopressin and oxytocin in the control of emotion and social behavior. (2010)
  • Author(s): Onaka T, Takayanagi Y
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2010-03-30
• [Presentation] Effects of i.c.v. administration of RFamide related peptide-1 upon release of stress-related hormones and anxiety-related behavior. (2010)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Roles of PrRP and oxytocin receptor in stress-induced increase of energy expenditure. (2010)
  • Author(s): Takayanagi Y, Nishimori K, Onaka T
  • Organizer: 14^<th> International Congress of Endocrinology (ICE2010)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-03-30
• [Presentation] Roles of PrRP in the control of energy metabolisms and stress responses. (2010)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 88^<th> Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 2010-03-29
• [Presentation] Role of prolactin-releasing peptide in stress-induced energy expenditure. (2009)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 32^<nd> Annual Meeting of the Japan Neuroscience Society.
  • Place of Presentation: Nagoya
  • Year and Date: 2009-09-18
• [Presentation] Prolactin-releasing peptide is impotant for relaying leptin signaling to reduce food intake and body weight. (2009)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 36^<th> International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-30
• [Presentation] Effects of i.c.v. administration of RFamide related peptides on plasma oxytocin concentrations in rats. (2009)
  • Author(s): Kaewwongse M, Takayanagi Y, Onaka T
  • Organizer: The 36^<th> International Congress of Physiological Sciences (IUPS2009)
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-07-28
• [Presentation] Oxygen consumption in prolactin-releasing peptide-deficient mice during stressful stimuli. (2009)
  • Author(s): Onaka T, Takayanagi Y
  • Organizer: British Society for Neuroendocrinology Annual Meeting 2009 (BSN2009)
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 2009-06-29
• [Presentation] Role of prolactin-releasing peptide in the control of energy expenditure. (2008)
  • Author(s): Takayanagi Y, Onaka T
  • Organizer: The 31^<st> Annual Meeting of the Japan Neuroscience Society, Neuroscience 2008
  • Place of Presentation: Tokyo
  • Year and Date: 2008-07-10