2010 Fiscal Year Final Research Report
Synchronization among heterogeneous oscillator cells in the suprachiasmatic nucleus, the circadian center.
| Project/Area Number |
20590240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kinki University |
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Principal Investigator |
SHIGEYOSI Yasufumi Kinki University, 医学部, 教授 (20275192)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Atsuko 近畿大学, 医学部, 准教授 (30077664)
NAGANO Mamoru 近畿大学, 医学部, 講師 (80155960)
KOINUMA Satoshi 近畿大学, 医学部, 助教 (10340770)
SUJINO Mitsugu 近畿大学, 医学部, 助教 (30460843)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 視交叉上核 / サーカデイアンリズム / 体内時計 / 概日リズム / 同期 |
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| Research Abstract |
To know the intercellular system that keeps the synchrony among oscillator neurons in the SCN, we developed two projects to delineate the intrinsic synchronizing systems. We got two bland new findings. (1) Synchrony between dorsomedial SCN (DMSCN) and ventrolateral SCN (VLSCN) is possibly attained by VIP and VPAC2 system. (2) We found that the SCN is divided into two parts in relevance to period of circadian rhythm. Medial small part containing oscillators with a period less than 24 hours and the rest of the SCN with a period longer than 24 hours.
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[Journal Article] Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro.2010
Author(s)
Yagita K, Horie K, Koinuma S, Nakamura W, Yamanaka I, Urasaki A, Shigeyoshi Y, Kawakami K, Shimada S, Takeda J, Uchiyama Y.
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Journal Title
proc Natl.Acad.Sci.U S A 107(8)
Pages: 3846-51
Peer Reviewed
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