2010 Fiscal Year Final Research Report
Study on roles of a novel NADPH oxidase isoform in the development of idiopathic pulmonary arterial hypertention
| Project/Area Number |
20590256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IWATA Kazumi Kyoto Prefectural University of Medicine, 医学研究科, 講師 (60305571)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNO Harukuni 京都府立医科大学, 医学研究科, 助教 (50420708)
KAKEHI Tomoko 京都府立医科大学, 医学研究科, プロジェクト研究員 (20433279)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 原発性肺高血圧症 / 活性酸素 / NADPH oxidase |
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| Research Abstract |
Pulmonary arterial hypertension is characterized by hypertrophy of small pulmonary arteries, which leads to right ventricular (RV) hypertrophy and heart failure. Nox1 is a catalytic subunit of NADPH oxidase known as a major source of superoxide production in vascular tissues. In Nox1-defcient mice (Nox1-/Y) hypertrophy of small pulmonary arteries and RV wall were observed. A significant decrease in number of apoptotic cells were demonstrated in pulmonary arterial smooth muscle cells (PASMC) isolated from Nox1-/Y. Dysfunction of Kv1.5, a voltage-dependent potassium channel, is one of the features reported in human and experimental PAH. A significant decrease in Kv1.5 protein and an increase in intracellular potassium levels were observed in Nox1-/Y PASMC.These results suggest that Nox1 plays a critical role in apoptosis of PASMC by regulating Kv1.5 expression and intracellular potassium levels.
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[Journal Article] Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.2010
Author(s)
Kang ES, Iwata K, Ikami K, Ham SA, Kim HJ, Chang KC, Lee JH, Kim JH, Park SB, Kim JH, Yabe-Nishimura C, Seo HG.
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Journal Title
Free Radic Biol Med. 50
Pages: 680-688
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[Journal Article] The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme : Possible involvement of the ERK1/2-JunB pathway.2008
Author(s)
Cevik MO, Katsuyama M, Kanda S, Kaneko T, Iwata K, Ibi M, Matsuno K, Kakehi T, Cui W, Sasaki M, Yabe-Nishimura C.
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Journal Title
Biochem Biophys Res Commun 374
Pages: 351-355
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