2010 Fiscal Year Final Research Report
The myocardial metabolic function and its control molecules in cardiac hypertrophy
| Project/Area Number |
20590257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka City University |
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Principal Investigator |
IZUMI Yasukatsu Osaka City University, 大学院・医学研究科, 准教授 (10347495)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心血管 / 代謝機能 / シグナル伝達 |
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| Research Abstract |
Takotsubo cardiomyopathy is an increasingly recognized clinical syndrome characterized by acute reversible apical ventricular dysfunction. We tried to make a new model of Takotsubo-like cardiomyopathy in non-human primates. Echocardiography revealed that repeated intravenous infusion of epinephrine overdose in cynomolgus monkeys induced Takotsubo-like cardiomyopathy, which is characterized by progressive left ventricle and depressed systolic function with severe hypokinesis in apical regions and hyperkinesis in the basal region. Although this cardiac dysfunction almost normalized after a month even without any treatment, metoprolol, a β-blocker, improved the decreased ejection fraction earlier than the control. This model is valuable in understanding the pathogenesis of Takotsubo cardiomyopathy and effectivity of β-blockers.
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[Journal Article] Microminipig, a Non-Rodent Experimental Animal Optimized for Life Science Research-Novel Atherosclerosis Model induced by High Fat and Cholesterol Diet.2011
Author(s)
Kawaguchil H, Miyoshi N, Miura N, Fujiki M, Horiuchi M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T, Tanimoto A, Yoshida H.
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Journal Title
J Pharmacol Sci 115
Pages: 115-121
Peer Reviewed
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[Journal Article] Novel microminipig model of atherosclerosis by high fat and high cholesterol diet, established in Japan.2010
Author(s)
Miyoshi N, Horiuchi M, Inokuchi Y, Miyamoto Y, Miura N, Tokunaga S, Fujiki M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T, Tanimoto A, Yasuda N, Yoshida H, Kawaguchi H.
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Journal Title
In Vivo 24
Pages: 671-680
Peer Reviewed
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