2010 Fiscal Year Final Research Report
A novel mechanism of glutathione synthesis in neuron
| Project/Area Number |
20590261
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Teikyo University |
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Principal Investigator |
AOYAMA Koji Teikyo University, 医学部, 講師 (00420943)
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| Project Period (FY) |
2008 – 2010
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| Keywords | グルタチオン / GTRAP3-18 / EAAC1 / 神経変性疾患 |
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| Research Abstract |
EAAC1 plays an important role in neuronal GSH synthesis. GTRAP3-18 is an EAAC1-binding protein to inhibit the function in neurons. However, it is still elusive that GTRAP3-18 negatively regulates neuronal GSH synthesis in vivo. In this study, we showed that intraventricular injection of GTRAP3-18 siRNA decreased GSHcontent in the hippocampus, while intraventricular injection of methyl β-cyclodextrin decreased GSH content with increased GTRAP3-18 expression in the hippocampus. These results suggest that GTRAP3-18 negatively regulates neuronal GSH synthesis in the hippocampus.
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