2010 Fiscal Year Final Research Report
Ischemic organ injury and sympathetic nervous system : Roles of endothelin and angiotensin, and sex difference
| Project/Area Number |
20590266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
MATSUMURA Yasuo Osaka University of Pharmaceutical Sciences, 薬学部, 教授 (40140230)
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| Co-Investigator(Kenkyū-buntansha) |
OHKITA Mamoru 大阪薬科大学, 薬学部, 講師 (60449824)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 心臓 / 虚血 / 再灌流 / 交感神経 / ノルアドレナリン / 性差 / 女性ホルモン |
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| Research Abstract |
In cases of cardiac ischemia, which leads to the development of angina pectoris and cardiac infarction, noradrenaline (NA) release from sympathetic nerve endings is known to be enhanced and involved in the pathogenesis of the ischemic cardiac injury. In the present study, we elucidated the possible mechanisms of the above enhancement of NA overflow. We also clarified that there was a sex difference in the NA overflow from the post-ischemic heart, i. e., the amount of NA released from the heart of females was less than that of males, and the post-ischemic cardiac injury was attenuated in cases of females. Furthermore, it was found that estrogens are responsible for this sex difference.
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