2011 Fiscal Year Final Research Report
Genomic analysis of immunosuppressant effect-related genes using fission yeast as a model system
| Project/Area Number |
20590268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
SHUNTOH Hisato 神戸学院大学, 総合リハビリテーション学部, 教授 (70206259)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 受容体 / チャネル / 輸送系 / シグナル情報伝達系 |
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| Research Abstract |
Calcineurin is a target of immunosuppressive drugs. We reported that calcineurin is implicated in membrane trafficking, cytokinesis, and cell morphogenesis, in which reorganization of actin cytoskeleton is involved, by screening and analysis of immunosuppressant-sensitive mutants in fission yeast. wsp1^+gene encodes a fission yeast Wiskott-Aldrich syndrome protein homolog, which plays a key role in integrating reorganization of action cytoskeleton. wsp1 null cells were immunosuppressant-sensitive. Analysis of immunosuppressant-sensitive mutants suggested that immunosuppressant side effect may be attributable to abnormality in membrane trafficking.
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