2010 Fiscal Year Final Research Report
Dynamics of TIP60 histone acetyltransferase complex in DNA damage response
| Project/Area Number |
20590272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
IKURA Tsuyoshi Tohoku University, 放射線生物研究センター, 准教授 (70335686)
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| Project Period (FY) |
2008 – 2010
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| Keywords | DNA損傷応答 / TIP60ヒストンアセチル化酵素 / ヒストンH2AX / アセチル化 / ユビキチン化 / ブロモドメイン / 機能的蛋白質複合体 |
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| Research Abstract |
Dynamics of TIP60 histone acetyltransferase complex in DNA damage response
To elucidate the role of the TIP60 histone acetyltransferase complex in DNA damage response, we analyzed the component of TIP60 complex by MS analysis. We identified the p120 bromodomain protein in the TIP60 complex. We found that p120 binds the acetylated histone H2AX in vitro and is required for the recruitment of UBC13 to damaged chromatin.
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[Journal Article] Methionine Adenosyltransferase II Serves As a Transcriptional Corepressor of Maf Oncoprotein.2011
Author(s)
Katoh, Y, Ikura, T., Hoshikawa, Y., Tashiro, S., Ohta, M., Kera, Y., Noda, T., Igarashi, K.
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Journal Title
Mol Cell. 41
Pages: 554-566.1
Peer Reviewed
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[Journal Article] ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.2010
Author(s)
Sun, J., Oma, Y., Harata, M., Kono, K., Shima, H., Kinomura, A., Ikura, T., Mizutani, S., Kanaar, R., Tashiro, S.
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Journal Title
Peer Reviewed
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[Journal Article] Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.2010
Author(s)
Niida H, Katsuno Y, Sengoku M, Shimada M, Yukawa M, Ikura M, Ikura T, Kohno K, Shima H, Suzuki H, Tashiro S, Nakanishi M.
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Journal Title
Genes Dev. 24
Pages: 333-338
Peer Reviewed
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[Journal Article] Proline cis/trans isomerase Pin1 regulates peroxisome proliferator-activated receptor {gamma} activity through the direct binding to the AF-1 domain.2010
Author(s)
Fujimoto Y, Shiraki T, Horiuchi Y, Waku T, Shigenaga A, Otaka A, Ikura T, Igarashi K, Aimoto S, Tate SI, Morikawa K.
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Journal Title
J Biol Chem. 285
Pages: 3126-32
Peer Reviewed
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[Journal Article] The human actin-related protein hArp5 : nucleo-cytoplasmic shuttling and involvement in DNA repair2009
Author(s)
Kitayama K, Kamo M, Oma Y, Matsuda R, Uchida T, Ikura T, Tashiro S, Ohyama, T, Winsor B, Harata M.
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Journal Title
Exp.CellRes. 15
Pages: 206-217
Peer Reviewed
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[Journal Article] Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin.2008
Author(s)
Dohi, Y, Ikura, T, Hoshikawa, Y, Katoh, Y, Ota, K, Nakanome, A., Muto, A., Omura, S,. Ohta, T., Ito, A., Yoshida, M., Noda, T., Igarashi, K.
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Journal Title
Nature Structural & Molecular Biology 15
Pages: 1246-1254
Peer Reviewed
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[Journal Article] Absence of Ku70 Gene Obliterates X-Ray-Induced lacZ Mutagenesis of Small Deletions in Mouse Tissues.2008
Author(s)
Uehara, Y., Ikehata, H., Komura, J., Ito, A., Ogata, M ., Itoh, T., Hirayama, R., Furusawa, Y., Ando, K., Paunesku, T., Gayle, E., Woloschak, G.E., Komatsu, K., Matsuura, S., Ikura, T., Kamiya, K., Ono, T.
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Journal Title
RADIATION RESEARCH 170
Pages: 216-223
Peer Reviewed
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[Journal Article] Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone crosstalk with H3K4 di- and tri-methylation.2008
Author(s)
Nakagawa, T., Kajitani, T., Togo, S., Masuko, N., Ohdan, H., Hishikawa, Y., Koji T., Matsuyama, T., Ikura T., Muramatsu, M., Ito, T.
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Journal Title
Genes Dev. 22
Pages: 37-49
Peer Reviewed
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