2010 Fiscal Year Final Research Report
Regulation of dendritic cell functions by CD47-SIRPα system
| Project/Area Number |
20590274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
KOBAYASHI Hisae Gunma University, 生体調節研究所, 技術専門職員 (80234839)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 樹状細胞 / SIRPα / 自然免疫 |
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| Research Abstract |
CD47 and SIRPα are transmembrane proteins and they constitute a cell-cell communication system by interacting their ectodomains. SIRPα predominatly expresses in dendritic cells and CD47-SIRPα system is important for regulation of immunity. In this research project, we have shown that CD47-SIRPα participates in regulation of induction of autoimmune diseases and homeostasis of dendritic cells. Furthermore, we found anti-SIRPα antibodies can regulate induction of autoimmune diseases.
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[Journal Article] Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues.2010
Author(s)
Saito Y., Iwamura H., Kaneko T., Ohnishi H., Murata Y., Okazawa H., Kanazawa Y., Sato-Hashimoto M., Kobayashi H., Oldenborg. P.-A., Naito M., Kaneko Y., Nojima Y., Matozaki T.
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Journal Title
Blood Vol.116
Pages: 3517-3525
Peer Reviewed
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