2010 Fiscal Year Final Research Report
Analysis of molecular mechanisms involving with the generation and the pathological condition of rhabdomyosarcoma induced by genetic recombination specifically in skeletal muscle
| Project/Area Number |
20590276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Noboru Mie University, 生命科学研究支援センター, 准教授 (00202135)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 横紋筋肉腫 / ras / p53 / 自家癌モデル動物 / 遺伝子改変動物 / がん性悪液質 / カヘキシー |
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| Research Abstract |
An generated animal model for rhabdomyosarcomas(RMSs) expressing K-rasG12V gene specifically in skeletal muscle by Cre/LoxP system on p53-/- background developed pleomorphic RMSs and severe cachexia with incidence of 100%. Gene expression profiling of cachectic and non-cachectic cell lines derived primary tumors suggested various molecules involved with the RMS tumor development and disease state.
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