2010 Fiscal Year Final Research Report
Analysis of physiological function of novel phospholipid-metabolizing enzymes involved in the formation of anandamide
| Project/Area Number |
20590284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
JIN Xinghua Kagawa University, 医学部, 外国人研究者 (50457339)
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| Research Collaborator |
UYAMA Toru 香川大学, 医学部, 助教 (30457337)
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| Project Period (FY) |
2008 – 2010
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| Keywords | N-アシルエタノールアミン / アナンダミド / カンナビノイド / 酵素 / N-アシルトランスフェラーゼ / リン脂質 |
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| Research Abstract |
N-Acyltransferase is an enzyme involved in the biosynthesis of anandamide (an endogenous ligand of cannabinoid receptors) and related fatty acid amide compounds in animal tissues, and transfers a fatty acyl chain from a glycerophospholipid molecule to phosphatidylethanolamine (PE) to form N-acyl-PE. We found a novel enzyme catalyzing this reaction, cloned its cDNA from rat, mouse, and human, and characterized its recombinant proteins.
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Research Products
(19 results)
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[Journal Article] cDNA cloning and characterization of human and mouse Ca^<2+>-independent phosphatidylethanolamine N-acyltransferases.2009
Author(s)
Jin, X.-H., Uyama, T., Wang, J., Okamoto, Y., Tonai, T., Ueda, N.
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Journal Title
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1791
Pages: 32-38
Peer Reviewed
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[Journal Article] The tumor suppressor gene H-Rev107 functions as a novel Ca^<2+>-independent cytosolic phospholipase A_<1/2> of the thiol hydrolase type.2009
Author(s)
Uyama, T., Morishita, J., Jin, X.-H., Okamoto, Y., Tsuboi, K., Ueda, N.
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Journal Title
Journal of Lipid Research 50
Pages: 685-693
Peer Reviewed
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