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2011 Fiscal Year Final Research Report

The regulation of actin assembly during myofibrillogenesis

Research Project

  • PDF
Project/Area Number 20590285
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKyushu University

Principal Investigator

TAKEYA Ryu  九州大学, 医学研究院, 講師 (50335981)

Project Period (FY) 2008 – 2011
Keywords細胞医化学
Research Abstract

In striated muscle, this actin filaments and thick filaments of myosin are highly organized to form myofibrils. However, little is known about the mechanism for organization of actin filaments in the contractile unit sarcomere. In the present study, we show that the mammalian formin Fhod3 regulates actin assembly and sarcomere organization in striated muscles.

  • Research Products

    (13 results)

All 2012 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart2012

    • Author(s)
      Kan-o M, Takeya R*, Taniguchi K, Tanoue Y, Tominaga R, Sumimoto H
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e34765

    • Peer Reviewed
  • [Journal Article] A conserved region between the TPR and activation domains of p67 phox participates in activation of the phagocyte NADPH oxidase2010

    • Author(s)
      Maehara Y, Miyano K, Yuzawa S, Akimoto R, Takeya R, Sumimoto H
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 31435-31445

    • Peer Reviewed
  • [Journal Article] A region N-terminal to the tandem SH3 domain of p47 phox plays a crucial role in the activation of the phagocyte NADPH oxidase2009

    • Author(s)
      Taura M, Miyano K, Minakami R, Kamakura S, Takeya R, Sumimoto H
    • Journal Title

      Biochem. J

      Volume: 419 Pages: 329-338

    • Peer Reviewed
  • [Journal Article] The mammalian formin Fhod3 regulates actin assembly and sarcomere organization in striated muscles2009

    • Author(s)
      Taniguchi K, Takeya R, Suetsugu S, Kan-o M, Narusawa M, Shiose A, Tominaga R, Sumimoto H.
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 29873-29881

    • Peer Reviewed
  • [Journal Article] The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fiber formation in endothelial cells2008

    • Author(s)
      Takeya R, Taniguchi K, Narumiya S, Sumimoto H
    • Journal Title

      EMBO J

      Volume: 27 Pages: 618-628

    • Peer Reviewed
  • [Journal Article] Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival.2008

    • Author(s)
      Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T.
    • Journal Title

      Int. J. Cancer

      Volume: 123 Pages: 787-792

    • Peer Reviewed
  • [Presentation] The essential role of mammalian formin FHOD3 in sarcomere organization during heart development2012

    • Author(s)
      Ryu Takeya, Meikun Kan-o, Takaya Abe, Naoyuki Kitajima, Motohiro Nishida, Ryuji Tominaga, Hitoshi Kurose, Hideki Sumimoto.
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20120529-0531
  • [Presentation] formin相同蛋白質Fhod3の心筋サルコメアにおける局在と機能2011

    • Author(s)
      神尾明君,武谷立,田ノ上禎久,富永隆治,住本英樹.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20111213-1216
  • [Presentation] formin相同蛋白質Fhod3のマウス胎仔、成獣、およびヒト心筋サルコメアにおける局在2011

    • Author(s)
      神尾明君,武谷立,田ノ上禎久,富永隆治,住本英樹.
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      横浜
    • Year and Date
      20110921-0924
  • [Presentation] Regulation of actin assembly and sarcomere organization in cardiomyocytes by the formin homology protein Fhod3.2009

    • Author(s)
      谷口賢一郎,武谷立,末次志郎,神尾明君,成澤慈,塩瀬明,富永隆治,住本英樹.
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      20091209-1212
  • [Presentation] formin相同蛋白質FHOD3の筋細胞における生理的役割2009

    • Author(s)
      武谷立,谷口賢一郎,住本英樹
    • Organizer
      平成21年度日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      20090516-0517
  • [Presentation] formin相同蛋白質FHOD3の活性制御機構の解明2009

    • Author(s)
      成澤慈,武谷立,住本英樹
    • Organizer
      平成21年度日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      20090516-0517
  • [Presentation] The formin-homology protein Fhos/FHOD : Mechanisms of action and physiological functions. BMB20082008

    • Author(s)
      Ryu Takeya, Kenichiro Taniguchi, Shuh Narumiya, Hideki Sumimoto.
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸.シンポジウム
    • Year and Date
      20081209-1212

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Published: 2013-07-31  

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