2010 Fiscal Year Final Research Report
Chimerism analysis in fingernails among recipients of allogeneic hematopoietic stem-cell transplants by examining the patterns of the short tandem repeat.
| Project/Area Number |
20590286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
IMANISHI Daisuke Nagasaki University, 病院, 助教 (30398169)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Yasushi 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40304943)
TOMONAGA Masao 長崎大学, 大学院・医歯薬学総合研究科, 教授 (40100854)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 移植・再生医療 / 再生医学 / 放射線 |
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| Research Abstract |
Allogeneic hematopoietic stem cell (HSC) transplantation by infusion of donor HSC is a treatment to replace patient blood cells with donor-derived hematopoietic tissue. However, it has been reported that donor cell exist in the non-hematopoietic tissues after transplantation. However, the fingernails, which is non-hematopoietic tissue, has not been investigaed. So, we examined whether donor DNA was in the fingernails after transplantation. The result showed that the donor DNA existed in the very high percentage. It is still unknown how this coexistence happens. Further examination is needed.
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