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2010 Fiscal Year Final Research Report

Analysis of common molecular mechanisms and pharmaceutical research in cancer invasion and angiogenesis

Research Project

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Project/Area Number 20590293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionOsaka Bioscience Institute

Principal Investigator

HASHIMOTO Ari  Osaka Bioscience Institute, 大学院・医学研究科, 助教 (60390803)

Research Collaborator 京都大学, 医学部
オックスフォード大学, Weatherall Institute of Molecular Medicine Cell Signalling
Project Period (FY) 2008 – 2010
Keywords血管新生 / 癌浸潤 / Arf6 / AMAP1 / ArfGEF / 乳癌 / チロシンリン酸化
Research Abstract

We have shown that GEP100 links EGFR signaling to Arf6 activation to induce invasive activities of some breast cancer cells. Our analyses demonstrate that the same GEP100-Arf6-AMAP1 pathway is essential for VEGF-induced angiogenesis activities, and that VEGFR2, via phospho-Tyr951, binds to the PH domain of GEP100 to activate the Arf6-AMAP1 pathway to induce angiogenesis. Moreover, we found the small compound that inhibits the interaction between GEP100 and VEGFR-2. The GEP100-Arf6-AMAP1 pathway, activated by receptor tyrosine kinases, appears to be common in angiogenesis and cancer invasion, and provide their new therapeutic targets from a pathological analysis.

  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.2009

    • Author(s)
      Sabe, H., Hashimoto, S., Morishige, M., Hashimoto, A., Ogawa, E., Nam, J.M, Miura, K., Yano, H., Onodera, Y.
    • Journal Title

      Traffic 10

      Pages: 982-993

    • Peer Reviewed
  • [Journal Article] The EGFR-GEP100-Arf6 pathway in breast cancer : Full invasiveness is not from the inside.2008

    • Author(s)
      Sabe, H., Hashimoto, S., Morishige, M., Hashimoto, A., Ogawa, E.
    • Journal Title

      Cell Adhesion & Migration. 103

      Pages: 7036-7041

    • Peer Reviewed
  • [Journal Article] GEP100 links EGFR signaling to Arf6 activation to induce breast cancer invasion.2008

    • Author(s)
      Morishige , M., Hashimoto, S., Ogawa, E., Toda, Y., Kotani, H., Hirose, M., Wei, S., Hashimoto, A., Yamada, A., Yano, H., Mazaki, Y., Kodama, H., Nio, Y., Manabe, Y., Wada, H., Kobayashi, H., ^*Sabe, H.
    • Journal Title

      Nat Cell Biol. 10

      Pages: 85-92

    • Peer Reviewed
  • [Presentation] TGFβ1 activates GEP100-Arf6-AMAP1 pathway to induce EMT, and possible relationship of this activation to cancer stemness2010

    • Author(s)
      橋本あり
    • Organizer
      第33回日本分子生物学会年会・第83 回日本生化学会大会合同大会
    • Place of Presentation
      ポスター発表 神戸
    • Year and Date
      2010-12-08
  • [Presentation] HGFR-mediated activation of GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness2010

    • Author(s)
      橋本あり
    • Place of Presentation
      口頭発表 大阪
    • Year and Date
      2010-09-23
  • [Presentation] GEP100-Arf6-AMAP1 pathway is activated by VEGFR2 and promotes vascular remodeling and VE-cadherin endocytosis in endothelial cells2010

    • Author(s)
      橋本あり
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      ポスター発表 大阪
    • Year and Date
      2010-05-19
  • [Presentation] 腫瘍血管における透過性亢進に関与する分子輸送のメカニズム及び病態の解明2009

    • Author(s)
      橋本あり
    • Organizer
      細胞内ロジスティックス斑会議
    • Place of Presentation
      口頭発表 沖縄
    • Year and Date
      2009-11-11
  • [Presentation] GEP100-Arf6-AMAP1-cortactin シグナル経路は癌浸潤と血管新生に共通である2008

    • Author(s)
      橋本あり
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会)
    • Place of Presentation
      シンポジウム口頭発表 神戸
    • Year and Date
      2008-12-12
  • [Presentation] Common usage of the GEP100-Arf6-AMAP1 pathway in tumor invasion, angiogenesis and vascular permeability2008

    • Author(s)
      橋本あり
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      ワークショップ口頭発表 名古屋
    • Year and Date
      2008-10-30
  • [Presentation] Common usage of the GEP100-Arf6-AMAP1 pathway in tumor invasion, angiogenesis and vascular permeability2008

    • Author(s)
      橋本あり
    • Organizer
      第20回欧州癌研究治療機関・米国国立ガン研究所・米国ガン学会合同シンポジウム『分子標的とがん治療』
    • Place of Presentation
      ポスター発表 ジュネーブ・スイス
    • Year and Date
      2008-10-22
  • [Presentation] Common usage of the GEP100-Arf6 signaling pathway in tumor invasion, angiogenesis, and vascular permeability2008

    • Author(s)
      橋本あり
    • Organizer
      Second JCA-AACR Special Joint Conference
    • Place of Presentation
      ポスター発表 淡路
    • Year and Date
      2008-07-15
  • [Presentation] Common usage of an Arf6-GEP100 signaling pathway in angiogenesis and tumor invasion2008

    • Author(s)
      橋本あり
    • Organizer
      ワークショップ
    • Place of Presentation
      口頭発表 横浜
    • Year and Date
      2008-07-01
  • [Book] (2008)がんの浸潤形質獲得過程における低分子量Gタンパク質Arf6シグナル伝達(実験医学増刊号)(vol.26(15))2008

    • Author(s)
      橋本茂、森重真毅、小川栄治、橋本あり、小野寺康仁、佐邊壽孝
    • Total Pages
      2349-2355
    • Publisher
      羊土社
  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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