2010 Fiscal Year Final Research Report
Functional analyses of transcription factors of ATF-2 gene family members by using knockout mouse
| Project/Area Number |
20590294
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
MAEKAWA Toshio The Institute of Physical and Chemical Research, 石井分子遺伝学研究室, 副主任研究員 (90201764)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | ATF-2 / ATF-7 / ストレス / 転写制御 / エピジェネティクス / 肥満 / 行動異常 / セロトニン |
|---|
| Research Abstract |
By the analyses of knockout mice of the ATF-2 gene family members, I have analyzed the physiological functions of ATF-2 gene family members. I have found that ATF-2 contribute to the developments of central nervous systems and macrophages. ATF-2 and CRE-BPa also contribute to the differentiations to the adipose tissue. On the other hand, ATF-7 represses the transcription of serotonin receptor 5b in the dorsal raphe nucleus in the brain stem. By the depletion of ATF-7, serotonin concentration was reduced and mouse showed abnormal behaviors.
|
Research Products
(13 results)
