2010 Fiscal Year Final Research Report
Biological roles of tumor-suppressor miR-34a in colon carcinogenesis
| Project/Area Number |
20590297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
TSUCHIYA Naoto National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所, ユニット長 (30322712)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 癌 / 細胞 / 組織 / シグナル伝達 / 発現制御 / マイクロRNA |
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| Research Abstract |
miR-34a is a tumor-suppressive miRNA, which represses cancer cell proliferation by inducing cell cycle arrest. In this study, we found positive feedback activation of p53 by miR-34a through the repression of endogenous inhibitors of p53. Furthermore, a functional screening method was established to quickly and efficiently isolate tumor-suppressive miRNAs. By using this method, a novel tumor-suppressor miR-22 was successfully identified.
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[Journal Article] Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.2011
Author(s)
Tsuchiya N, Izumiya M, Ogata-Kawata H, Okamoto K, Fujiwara Y, Nakai M, Okabe A, Schetter AJ, Bowman ED, Midorikawa Y, Sugiyama Y, Aburatani H, Harris CC, Nakagama H
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