2010 Fiscal Year Final Research Report
Biological role of the proton-sensing G-protein coupled receptor TDAG8
| Project/Area Number |
20590305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHII Satoshi The University of Tokyo, 大学院・医学系研究科, 教授 (10300815)
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| Project Period (FY) |
2008 – 2010
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| Keywords | LLC細胞 / プロトンセンサー / 癌 |
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| Research Abstract |
T cell death-associated gene 8 (TDAG8) is an extracellular pH-sensing G protein-coupled receptor. In this study, we show that TDAG8-overexpressing mouse Lewis lung carcinoma (LLC) cells enhance tumor development in animal models. The exogenously expressed TDAG8 rendered LLC cells resistant to acidic culture conditions by PKA and ERK in vitro. Provided that TDAG8 is overexpressed in various tumors and tumor cell lines, our data suggest that TDAG8 enhances tumorigenesis by linking tumor-induced acidity to tumor cell survival/proliferation.
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