2010 Fiscal Year Final Research Report
Real time imaging & morphological analysis of cell death induced by chemotherapy & radiotherapy in vivo
| Project/Area Number |
20590307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
SHIRAI Toshiharu Kanazawa University, 医学系, 助教 (20397186)
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| Project Period (FY) |
2008 – 2010
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| Keywords | がん細胞 / 形態学的細 / リアルタイム / GFP / RFP / in vivo / 紫外線 |
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| Research Abstract |
We observed morphology of in vivo cell death, induced by anti-cancer agent or ultraviolet light, using dual-color cancer cells in which GFP was expressing in nucleus and RFP in cytoplasm. As results, we found several morphologies of cell death, even though there is usually said to be only two categories for cell death, apoptosis and necrosis. We also found that those morphologic differences were dependent on cell line, anti-cancer drug, and wave length of radiation.
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