2010 Fiscal Year Final Research Report
Analysis of the pathological roles of ER stress-induced transcriptional factors
| Project/Area Number |
20590310
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
GOTOH Tomomi Kumamoto University, 教育学部, 教授 (20264286)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ENDO Motoyoshi 熊本大学, 大学院・生命科学研究部, 助教 (40398243)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Keywords | 小胞体ストレス / マクロファージ / アポトーシス / 炎症 / 動脈硬化 |
|---|
| Research Abstract |
ER stress pathway is induced by various stresses from both inside and outside the cells. In this study, we found that the activation patterns of ER stress sensors differ depending on the nature of inducing-stimuli. Then, the ER stress response pathway including the ER stress induced-transcription factor CHOP differ and play different roles, such as preventing cells, inducing apoptosis and inducing inflammation.
|
-
[Journal Article] (*corresponding author) The Endoplasmic Reticulum Stress-CHOP Pathway-mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques.2010
Author(s)
H.Tsukano, T.Gotoh, M.Endo, K.Miyata, H.Tazume, T.Kadomatsu, M.Yano, T.Iwawaki, K.Kohno, K.Araki, H.Mizuta, Y.Oike.
-
Journal Title
Arterioscler.Thromb.Vasc.Biol. 30
Pages: 1925-1932
Peer Reviewed
-
-
-
-
-
[Journal Article] Positive role of CHOP, a transcription factor involved in the ER stress response in the development of colitis.2009
Author(s)
T.Namba, K.Tanaka, Y., Ito, T.Ishihara, T.Hoshino, T.Gotoh, M.Endo, K.Sato, T.Mizushima.
-
Journal Title
Am.J.Pathol. 174
Pages: 1786-1798
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
