2010 Fiscal Year Final Research Report
Phasogenesis study of XOR mutant knock-in mouse.
| Project/Area Number |
20590317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OKAMOTO Ken Nippon Medical School, 医学部, 准教授 (60267143)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Tomohiro 日本医科大学, 医学部, 助教 (20297930)
KUSANO Teruo 日本医科大学, 医学部, 助教 (30434129)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子病態学 / スーパーオキシド |
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| Research Abstract |
We designed and constructed O2- hyperproduction XOR mutant knoched-in mouse which and dehydrogenase-type locked mutant knoched-in mouse. We propagated the starins. We purified mutant XOR from the knocked-in mutant mouse liver and confirmed the hyper production of superoxide anion. We are observing the phenotypes of the mutans and surveying pathological findings of organs.
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