2010 Fiscal Year Final Research Report
The molecular mechanisms of the convergence in the early stage of the cell growth and adhesion signalings enhanced by glycosphingolipids
| Project/Area Number |
20590319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Chubu University |
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Principal Investigator |
FURUKAWA Keiko Chubu University, 生命健康科学部, 教授 (50260732)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 酸性スフィンゴ糖脂質 / GD3 / メラノーマ / インテグリン / 脂質ラフト / シグナル伝達 |
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| Research Abstract |
Glycosphingolipid, GD3 is widely expressed in human malignant melanoma cells and tumors. In this study, we analyzed the molecular mechanisms for the convergence in the initial stage of the cell growth and adhesion signalings enhanced by GD3. Our results suggested that the signaling molecules were phosphorylated through the growth factor receptors more strongly in GD3-expressing cells than in GD3 negative cells. This was also the case for signaling via cell adhesion probably due to the assembly and clustering of integrins in lipid rafts, leading to the malignant properties of melanomas under GD3 expression.
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[Journal Article] Functional activation of Src family kinase Yes is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.2011
Author(s)
Hamamura K., Tsuji M., Hotta H., Ohkawa Y., Takahashi M., Shibuya H., Nakashima H., Yamauchi Y., Hashimoto N., Hattori H., Ueda M., Furukawa K.
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Journal Title
Peer Reviewed
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[Journal Article] The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.2009
Author(s)
Greenshields K.N., Halstead S.K., Zitman F.M., Rinaldi S., Brennan K.M., O'Leary C., Chamberlain L.H., Easton A., Roxburgh J., Pediani J., Furukawa K., Goodyear C.S., Plomp J.J., Willison H.J.
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Journal Title
J.Clin.Invest. 119
Pages: 595-610
Peer Reviewed
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