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2009 Fiscal Year Final Research Report

Analyses of DNA methylation and histone methylation changes in human malignancies

Research Project

  • PDF
Project/Area Number 20590325
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

KONDO Yutaka  Aichi Cancer Center Research Institute, 分子腫瘍学部, 室長 (00419897)

Research Collaborator 安 炳九  愛知県がんセンター(研究所), 分子腫瘍学部, リサーチレジデント
新城 恵子  愛知県がんセンター(研究所), 分子腫瘍学部, 連携大学院生
Project Period (FY) 2008 – 2009
Keywords分子腫瘍学 / エピジェネティクス / 遺伝子制御機構
Research Abstract

In the current study, to clarify the contribution of epigenetic abnormalities to the human tumorigenesis, we conducted high-throughput analysis of DNA methylation, lysine 27 trimethylation and genetic alterations in human malignancies. Using malignant mesothelioma as a model, we demonstrated a characteristic epigenetic profile of human mesothelioma and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor-suppressor genes in mesothelioma and could serve as diagnostic or prognostic targets.

  • Research Products

    (15 results)

All 2010 2009 2008 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.2010

    • Author(s)
      Shen L, Kantarjian H, Kondo Y, (他13名、11番目).
    • Journal Title

      J Clin Oncol. Vol.28,No.4

      Pages: 605-13

    • Peer Reviewed
  • [Journal Article] Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.2009

    • Author(s)
      Goto Y, Shinjo K, Kondo Y, (他19名、3番目、責任著者)
    • Journal Title

      Cancer Res. Vol.69,No.23

      Pages: 9073-82

    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Ohno M, Natsume A, Kondo Y, (他6名、3番目)
    • Journal Title

      Mol Cancer Res. Vol.7,No.12

      Pages: 2022-30

    • Peer Reviewed
  • [Journal Article] Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling.2009

    • Author(s)
      Yuki K, Natsume A, Yokoyama H, Kondo Y, (他6名、4番目), Ohno M, Kato T, Chansakul P, Ito M, Kim S, Wakabayashi T.
    • Journal Title

      Cancer Lett. Vol.284,No.1

      Pages: 71-9

    • Peer Reviewed
  • [Journal Article] A characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.

    • Author(s)
      An B, Kondo Y, (他18名、2番目、責任著者)
    • Journal Title

      Int J Cancer (in press)

    • Peer Reviewed
  • [Presentation] 「消化器癌におけるエピジェネティクス」がん細胞を制御するDNAメチル化とヒストン修飾の網羅的解析.2009

    • Author(s)
      近藤豊
    • Organizer
      第17回日本消化器関連学会
    • Place of Presentation
      基調講演、京都
    • Year and Date
      2009-10-15
  • [Presentation] 「Microarray-based approaches to cancer epigenetics」ChiP-chip法をはじめとした網羅的エピジェネティクス解析法のがん研究への応用2009

    • Author(s)
      近藤豊
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      モーニングレクチャー、横浜
    • Year and Date
      2009-10-03
  • [Presentation] 「Epigenetics in Development and Disease Conference」Role of histone H3 lysine 27 tri-methylation in human brain tumor-propagating cells.2009

    • Author(s)
      Kondo Y
    • Organizer
      The 4th Asian Epigenomics Meeting.
    • Place of Presentation
      Symposium. Singapore
    • Year and Date
      2009-08-25
  • [Presentation] 「DNA Methylation & Chromatin Remodeling in Cancer」Role of DNA methylation and histone modifications in human neoplasia.2009

    • Author(s)
      Kondo Y
    • Organizer
      The 18th CRI Cancer Symposium.
    • Place of Presentation
      Symposium. Seoul, Korea
    • Year and Date
      2009-06-05
  • [Presentation] 「At the Front of Epigenetic Research」Cross-talk of DNA methylation and histone methylation in human cancers.2009

    • Author(s)
      Kondo Y
    • Organizer
      Avison Biomedical Symposium.
    • Place of Presentation
      Symposium. Seoul, Korea
    • Year and Date
      2009-01-17
  • [Presentation] 「Cancer Epigenetics」Role of histone methylation in human cancers.2008

    • Author(s)
      Kondo Y
    • Organizer
      Northeastern Asian Symposium on Cancer Epigenetics.
    • Place of Presentation
      Symposium. Jeju, Korea
    • Year and Date
      2008-11-05
  • [Book] Inflammation-related aberrant patterns of DNA methylation: detection and role in epigenetic deregulation of cancer cell transcriptome2009

    • Author(s)
      Suzuki H, Toyota M, Kondo Y, Shinomura Y. Humana Press
    • Total Pages
      55-69
    • Publisher
      Methods in Molecular Medicine
  • [Book] Chromatin Remodeling(Encyclopedia in Cancer)2009

    • Author(s)
      Kondo Y.
    • Total Pages
      4
    • Publisher
      Springer
  • [Remarks] ホームページ等

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-03.html#02

  • [Patent(Industrial Property Rights)] 悪性中皮腫の検出のための方法及びキット2009

    • Inventor(s)
      近藤豊、関戸好孝
    • Industrial Property Rights Holder
      近藤豊、関戸好孝
    • Industrial Property Number
      特許
    • Filing Date
      2009-06-05
    • Acquisition Date
      2009-06-05

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Published: 2011-06-18   Modified: 2016-04-21  

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