2010 Fiscal Year Final Research Report
Mechanisms of diseases by chromosomal translocation
| Project/Area Number |
20590326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
KINOSHITA Kazuo Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員 (50293874)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 分子腫瘍学 / 染色体転座 / 染色体異常 / DNA組換え / 遺伝子間距離 / 染色体テリトリー / がん |
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| Research Abstract |
Chromosomal Translocations are one of major causes of various diseases including cancer, psychiatric disorders, and congenital anomalies. Understanding these diseases requires a technique to experimentally recapitulate diseases-specific chromosomal translocations. We improved previous methods to enable easier and quicker manipulation of mammalian chromosomes. Using this technique, we demonstrated recapitulations of two-types of cancer-causing chromosomal translocations and induction of intra-chromosomal duplication, deletion, and inversion. In addition, we applied it to measurement of distance between two genetic loci.
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