2010 Fiscal Year Final Research Report
Novel role of ALOX5 (L22) in the control of antibody production
| Project/Area Number |
20590347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ICHIMIYA Shingo Sapporo Medical University, 保健医療学部, 教授 (30305221)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Alox5 / 慢性炎症 / ナイーブB細胞 / メモリーB細胞 / 濾胞ヘルパーT細胞 / 免疫トレランス / アレルギー / 感染症 / 悪性リンパ腫 |
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| Research Abstract |
We have previously reported L22 mAb with which human primary resting B cells and other immune cells of lymphoid follicles are well defined. In this study, we first identifiedL22 Ag as arachidonate 5-lipoxyganase (Alox5) and our experimental results illustrated the novel role of Alox5 during the process of specific antibody production by managing naive and memory B cells as well as follicular helper T cells in vivo. Because Alox5 is a key enzyme giving lipid mediators like leukotrienes, further investigations focusing on metabolome may provide new insights into the mechanisms of innate and adaptive immune responses and the pathogenesis of allergic and chronic inflammatory disorders (Nagashima T, et al. American Journal of Pathology, 2011).
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Research Products
(41 results)
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[Journal Article] Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.2011
Author(s)
Nagashima T, Ichimiya S, Kikuchi T, Saito Y, Matsumiya H, Ara S, Koshiba S, Zhang J, Hatate C, Tonooka A, Kubo T, Ye RC, Hirose B, Shirasaki H, Izumi T, Takami T, Himi T, Sato N.
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Journal Title
Am J Pathol. 178
Pages: 222-232
Peer Reviewed
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[Journal Article] Immunogenic enhancement and clinical effect by type-I interferon of anti-apoptotic protein, survivin-derived peptide vaccine, in advanced colorectal cancer patients.2011
Author(s)
Kameshima H, Tsuruma T, Torigoe T, Takahashi A, Hirohashi Y, Tamura Y, Tsukahara T, Ichimiya S, Kanaseki T, Iwayama Y, Sato N, Hirata K.
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Journal Title
Cancer Sci. Epub ahead of print 10.1111/j.1349-7006
Pages: 01918
Peer Reviewed
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[Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.2011
Author(s)
Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N.
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Journal Title
Toxicol Appl Pharmacol. 250
Pages: 29-38
Peer Reviewed
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[Journal Article] Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.2010
Author(s)
Kamekura R, Kojima T, Takashima A, Koizumi J, Ogasawara N, Go M, Takano K, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
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Journal Title
Histochem Cell Biol. 133
Pages: 339-48
Peer Reviewed
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[Journal Article] Induction of JAM-A during differentiation of human THP-1 dendritic cells.2009
Author(s)
Ogasawara N, Kojima T, Go M, Fuchimoto J, Kamekura R, Koizumi J, Ohkuni T, Masaki T, Murata M, Tanaka S, Ichimiya S, Himi T, Sawada N.
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Journal Title
Biochem Biophys Res Commun. 389
Pages: 543-549
Peer Reviewed
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[Journal Article] Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells.2009
Author(s)
Tonooka A, Kubo T, Ichimiya S, Tamura Y, Ilmarinen T, Ulmanen I, Kimura S, Yokoyama S, Takano Y, Kikuchi T, Sato N.
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Journal Title
Biochem Biophys Res Commun. 379
Pages: 765-770
Peer Reviewed
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[Journal Article] Prognostic impact and immunogenicity of a novel osteosarcoma antigen, papillomavirus binding factor, in patients with osteosarcoma.2008
Author(s)
Tsukahara T, Kawaguchi S, Torigoe T, Kimura S, Murase M, Ichimiya S, Wada T, Kaya M, Nagoya S, Ishii T, Tatezaki S, Yamashita T, Sato N.
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Journal Title
Cancer Sci. 99
Pages: 368-75
Peer Reviewed
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