2010 Fiscal Year Final Research Report
Activation of signal transduction pathway by aberration of oncogenes : comprehensive analysis and application for multi-molecular targeting therapy
| Project/Area Number |
20590351
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
DOBASHI Yoh Jichi Medical University, 医学部, 准教授 (90231456)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Syunsuke 自治医科大学, 医学部, 教授 (10245037)
YANAGAWA Takashi 群馬大学, 医学部, 助教 (50294971)
KITAGAWA Masatoshi 浜松大学, 医学部, 教授 (50294971)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Hirochika 山梨大学, 医学部・附属病院, 助手 (00374166)
SATO Eiiti 山梨大学, 医学工学総合研究部, 助教 (80293455)
OOI Akishi 金沢大学, 医学系研究科, 教授 (50160411)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 呼吸器 / 縦隔 |
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| Research Abstract |
The involvement of epidermal growth factor receptor (EGFR) cascade was analyzed in lung carcinomas and in soft tissue sarcoma. Overexpression/activation of EGFR was observed in 37% and constitutive activation of cascade was found in 11%. Mutation of EGFR was observed in 24% and associated with cell proliferation and metastasis. Increase of AKT genes were found in 45% with reciprocal relation against increase of EGFR gene. In sarcoma, mTOR activation was associated with morphogenesis in tumors of neural and skeletal muscle origin.
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[Journal Article] Paradigm of kinase-driven pathway downstream of EGFR/Akt in human lung carcinomas.2011
Author(s)
Dobashi, Y., Suzuki, S., Kimura, M., Matsubara, H., Tsubochi, H., Imoto, I., Ooi, A.
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Journal Title
Hum. Pathol. 42(2)
Pages: 214-26
Peer Reviewed
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[Journal Article] Gene Amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus.2010
Author(s)
Ooi, A., Zen, Y., Ninomiya, I., Tajiri, Y., Suzuki1, S., Kobayashi, H., Imoto, I., Dobashi, Y.
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Journal Title
Pathol Int. 60(6)
Pages: 466-471
Peer Reviewed
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[Journal Article] Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer.2010
Author(s)
Suzuki, S., Dobashi, Y., Hatakeyama, Y., Tajiri, R., Fujimura, T., Heldin, C.H., Ooi, A.
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Journal Title
Peer Reviewed
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[Journal Article] Critical and diverse involvement of the Akt/mTOR signaling in human lung carcinomas.2009
Author(s)
Dobashi, Y., Suzuki, S., Matsubara, H., Kimura, M., Endo, S., Ooi, A.
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Journal Title
Cancer 115(1)
Pages: 107-118
Peer Reviewed
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[Journal Article] Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinomas.2009
Author(s)
Ooi, A., Suzuki, S., Nakazawa, K., Itakura, J., Imoto, I., Nakamura, H., Dobashi, Y.
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Journal Title
Anticancer Res. 29(1)
Pages: 19-26
Peer Reviewed
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[Journal Article] High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers.2009
Author(s)
Shimada, M., Kitagawa, K., Dobashi, Y., Isobe, T., Hattori, T., Uchida, C., Abe, K., Kotake, Y., Oda, T., Suzuki., Hashimoto, K., Kitagawa, M.
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Journal Title
Cancer Science 100(5)
Pages: 866-872
Peer Reviewed
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[Journal Article] EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors.2009
Author(s)
Dobashi, Y., Suzuki, S., Sato, E., Hamada, Y., Yanagawa, T., Ooi, A.
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Journal Title
Mod.Pathol. 22(10)
Pages: 1328-1340
Peer Reviewed
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[Journal Article] Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy : a possible association with autocrine motility factor/phosphoglucose isomerase expression.2008
Author(s)
Sato, J., Yanagawa, T., Dobashi, Y., Yamaji, T., Takagishi, K., Watanabe, H.
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Journal Title
Clin.Exp.Metasta. 25(4)
Pages: 427-435
Peer Reviewed
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[Remarks] ホームページ等
