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2010 Fiscal Year Final Research Report

A functional role of Par-4 in endometrial tumorigenesis

Research Project

  • PDF
Project/Area Number 20590352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKitasato University

Principal Investigator

SAEGUSA Makoto  Kitasato University, 医学部, 教授 (00265711)

Project Period (FY) 2008 – 2010
KeywordsPar-4 / 子宮内膜癌 / アポトーシス / 細胞増殖
Research Abstract

Constitutively high levels of Par-4 expression were observed in epithelial cells through the menstrual cycle, in contrast to the transient up-regulation in stromal components in the menstrual stage, positively correlated with the phospho-p65 and apoptosis. Most ECs exhibited significant down-regulation, with positive links only to pp65 expression. Transfection of p65 led to transactivation of Par-4. Overexpression of Par-4 resulted in induction of not only apoptosis but also senescence, through changes in expression of bcl-2 and p21WAF1, respectively. Together, these findings suggest that a signaling cascade involving sequential activation of NF-_κB/p65 and Par-4 may participate in relatively early events of endometrial tumorigenesis, leading to modulation of cell kinetics including apoptosis and cell cycle progression.

  • Research Products

    (2 results)

All 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Transcriptional regulation of pro-apoptotic Par-4 by NF-kB/p65 and its function in controlling cell kinetics during early events in endometrial tumorigenesis.2010

    • Author(s)
      Saegusa M, Hashimura M, Kuwata T, Okayasu I.
    • Journal Title

      J Pathol 221

      Pages: 26-36

    • Peer Reviewed
  • [Presentation] アポトーシス関連遺伝子Par-4 による子宮内膜細胞動態調節機構と発癌2010

    • Author(s)
      三枝信、橋村美紀、桑田健、岡安勲
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20100500

URL: 

Published: 2012-01-26   Modified: 2016-04-21  

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