2010 Fiscal Year Final Research Report
Insufficient crosstalk between epithelium and stroma in chronic inflammation-carcinoma sequence: Analysis of a disease model
| Project/Area Number |
20590353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
OKAYASU Isao Kitasato University, 医学部, 名誉教授 (20014342)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Tsutomu 北里大学, 医学部, 講師 (90316943)
MIKAMI Tetuo 北里大学, 医学部, 准教授 (90286352)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 慢性炎症 / 発がん / 間質細胞 / 上皮細胞 / 潰瘍性大腸炎 / 粘膜リモデリング |
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| Research Abstract |
As organ-specific chronic inflammation-carcinoma sequence, we have analyzed ulcerative colitis (UC)-colorectal carcinoma system, and shown alterations of crosstalk between mucosal crypt epithelia and stromal cells, with decrease of subepithelial myofibroblasts and acceleration of genomic instability of interstitial cells, as well as mucosal remodeling, relating to tumorigenesis.
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