2010 Fiscal Year Final Research Report
Expression of sphingosine-1-phosphate receptors in mantle cell lymphoma and its practical application
| Project/Area Number |
20590357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SADAHIRA Yoshito Kawasaki Medical School, 医学部, 教授 (30178694)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Hideho 川崎医科大学, 医学部, 教授 (70191830)
TSUCHIYAMA Junjiro 川崎医科大学, 医学部, 講師 (50454806)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 血液 |
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| Research Abstract |
In this study, we found that sphingosine-1-phopshate (S1PR1) was strongly expressed in mantle cell lymphoma and adult T-cell leukemia/lymphoma and S1PR1 immunohistochemistry can be used as a robust means for the diagnosis of mantle cell lymphoma in formalin-fixed and paraffin-embedded sections. We further studied the impacts of FTY 720 on mantle cell lymphoma cells and HTLV-1 infected T-cells with high S1PR1 expression. It showed possibility that FTY 720 of 10uM concentration suppresses cell proliferation and survival of these cells by activating PP2A whereas that of 1 to 10nM concentrations suppresses serum-induced cell motility via FTY720 phosphate /S1PR1 signaling.
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