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2010 Fiscal Year Final Research Report

Global analysis for epigenetic alterations of hepatic stellate cells in the transformation using Gia-sequencing method.

Research Project

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Project/Area Number 20590370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionIwate Medical University

Principal Investigator

MASUDA Tomoyuki  Iwate Medical University, 医学部, 教授 (10199698)

Co-Investigator(Kenkyū-buntansha) MAESAWA Chihaya  岩手医科大学, 医学部, 教授 (10326647)
OIKAWA Hiroki  岩手医科大学, 医, 講師 (50285582)
Project Period (FY) 2008 – 2010
Keywords肝 / 線維症 / 星細胞 / miRNA / epigenetics
Research Abstract

We intensively examined on hepatic stellate cells (HSC) for the treatment strategy of liver fibrosis. The present study focused on epigenetic alterations within the process of HSCs transformation. Using Gia-base sequencing method, global alterations of DNA methylation were examined in HSC under the condition of HDAC inhibitor (TSA) and interferon (IFN)-γ. Of them, genes relating pluripotency of stem cells were altered, and the nucleus accumbens associated-1 (NACC1) might be an important factor along with cMYC and NANOG. These transition of HSC might be induced though epigenetic alterations.

  • Research Products

    (18 results)

All 2011 2010 2009 2008 Other

All Journal Article (17 results) Remarks (1 results)

  • [Journal Article] Down-regulation of microRNA-211 is involved in expression of preferentially expressed antigen of melanoma (PRAME) in melanoma cells.2011

    • Author(s)
      E. Sakaurai, C Maesawa
    • Journal Title

      Int J Oncol in press

  • [Journal Article] Accumbens-Associated 1 Contributes to Cortactin Deacetylation and Augments the Migration of Melanoma Cells.2011

    • Author(s)
      K. Tsunoda, H. Oikawa, H. Tada, Y. Tatemichi, S. Muraoka, S. Miura, M. Shibazaki, F. Maeda, K. Takahashi, T. Akasaka, T. Masuda, C. Maesawa, Nucleus
    • Journal Title

      J Invest Dermatol in press

  • [Journal Article] Non-invasive evaluation of liver fibrosis using acoustic radiation force impulse imaging in chronic hepatitis patients with hepatitis C virus infection.2010

    • Author(s)
      H. Kuroda, K. Kakisaka, Y. Tatemichi, K. Sawara, Y. Miyamoto, K. Oikawa, A. Miyasaka, Y. Takikawa, T. Masuda, K. Suzuki
    • Journal Title

      Hepatogastroenterology 57

      Pages: 1203-1207

  • [Journal Article] Detection of human papillomavirus in a urothelial carcinoma mimicking urethral caruncle.2010

    • Author(s)
      Y. Tatemichi, H. Oikawa, C. Maesawa, J. Ambo, M. Sato, H. Koike, T. Sata, T. Fujioka, T. Masuda
    • Journal Title

      Int J Urol 17

      Pages: 189-191

  • [Journal Article] Association of the TNF-{alpha}-C-857T polymorphism with resistance to the cholesterol-lowering effect of HMG-CoA reductase inhibitors in type 2 diabetic subjects.2010

    • Author(s)
      T. Takahashi, K. Takahashi, M. Yamashina, C. Maesawa, T. Kajiwara, H. Taneichi, N. Takebe, Y. Kaneko, T. Masuda, J. Satoh
    • Journal Title

      Diabetes Care 33

      Pages: 463-466

  • [Journal Article] Expression profiles of nestin in vascular smooth muscle cells in vivo and in vitro.2010

    • Author(s)
      H. Oikawa, K. Hayashi, C. Maesawa, T. Masuda, K. Sobue
    • Journal Title

      Exp Cell Res 316

      Pages: 940-950

  • [Journal Article] Immunohistochemical Study of HER2 and TUBB3 Proteins in Extramammary Paget Disease.2010

    • Author(s)
      A. Miyamoto, K. Akasaka, H. Oikawa, T. Akasaka, T. Masuda, C. Maesawa
    • Journal Title

      Am J Dermatopathol

  • [Journal Article] Enhanced goblet cell hyperplasia in HDC knockout mice with allergic airway inflammation.2009

    • Author(s)
      K. Yamauchi, H.M. Piao, T. Nakadate, T. Shikanai, Y. Nakamura, H. Ito, T. Mouri, H. Kobayashi, C. Maesawa, T. Sawai, H. Ohtsu, H. Inoue
    • Journal Title

      Allergol Int 58

      Pages: 125-134

  • [Journal Article] Spontaneous [Ca2+]i oscillations in G1/S phase-synchronized cells.2009

    • Author(s)
      A.D. Russa, C. Maesawa, Y. Satoh
    • Journal Title

      J Electron Microsc (Tokyo) 58

      Pages: 321-329

  • [Journal Article] Ontogeny of reticular framework of white pulp and marginal zone in human spleen : immunohistochemical studies of fetal spleens from the 17th to 40th week of gestation.2009

    • Author(s)
      T. Satoh, E. Sakurai, H. Tada, T. Masuda
    • Journal Title

      Cell Tissue Res 336

      Pages: 287-297

  • [Journal Article] Differential microRNA expression between bone marrow side population cells and hepatocytes in adult mice.2009

    • Author(s)
      Y. Nagata, C. Maesawa, H. Tada, Y. Takikawa, A. Yashima-Abo, T. Masuda
    • Journal Title

      Int J Mol Med 24

      Pages: 35-43

  • [Journal Article] Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease.2009

    • Author(s)
      Y. Minami, M. Satoh, C. Maesawa, Y. Takahashi, T. Tabuchi, T. Itoh, M. Nakamura
    • Journal Title

      Eur J Clin Invest 39

      Pages: 359-367

  • [Journal Article] DNA hypomethylation at the CpG island is involved in aberrant expression of the L1 cell adhesion molecule gene in colorectal cancer.2009

    • Author(s)
      K. Kato, C. Maesawa, T. Itabashi, K. Fujisawa, K. Otsuka, S. Kanno, H. Tada, Y. Tatemichi, K. Kotani, H. Oikawa, T. Sugai, G. Wakabayashi, T. Masuda
    • Journal Title

      Int J Oncol 35

      Pages: 467-476

  • [Journal Article] Loss of class III beta-tubulin induced by histone deacetylation is associated with chemosensitivity to paclitaxel in malignant melanoma cells.2009

    • Author(s)
      K. Akasaka, C. Maesawa, M. Shibazaki, F. Maeda, K. Takahashi, T. Akasaka, T. Masuda
    • Journal Title

      J Invest Dermatol 129

      Pages: 1516-1526

  • [Journal Article] Downregulation of miR-138 is associated with overexpression of human telomerase reverse transcriptase protein in human anaplastic thyroid carcinoma cell lines.2008

    • Author(s)
      S. Mitomo, C. Maesawa, S. Ogasawara, T. Iwaya, M. Shibazaki, A. Yashima-Abo, K. Kotani, H. Oikawa, E. Sakurai, N. Izutsu, K. Kato, H. Komatsu, K. Ikeda, G. Wakabayashi, T. Masuda
    • Journal Title

      Cancer Sci 99

      Pages: 280-286

  • [Journal Article] Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells.2008

    • Author(s)
      N. Izutsu, C. Maesawa, M. Shibazaki, H. Oikawa, T. Shoji, T. Sugiyama, T. Masuda
    • Journal Title

      Int J Oncol 32

      Pages: 1227-1235

  • [Journal Article] Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.2008

    • Author(s)
      H. Itabashi, C. Maesawa, H. Oikawa, K. Kotani, E. Sakurai, K. Kato, H. Komatsu, H. Nitta, H. Kawamura, G. Wakabayashi, T. Masuda
    • Journal Title

      Hepatol Res 38

      Pages: 601-613

  • [Remarks] ホームページ等

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Published: 2012-01-26   Modified: 2016-04-21  

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