2010 Fiscal Year Final Research Report
Relation between cell morphology and higher-order or angstrom level alteration of chromosomes and DNA architecture
| Project/Area Number |
20590373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MURATA Shin-ichi Saitama Medical University, 医学部, 教授 (20229991)
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| Project Period (FY) |
2008 – 2010
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| Keywords | Chromosome territory / Subchromosomal positioning / Microscopic FRET / FISH / Epidermal differentiation complex / DNA |
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| Research Abstract |
In this study, we present that
i) abnormal chromosome territories (CTs) of the CS10, CS18, and CS19 in thyroid carcinomas.
ii) relation between of nuclear atypia and number of chromosomes/genes in urothelial carcinomas of the urinary bladder.
iii) change of subchromosomal positioning (SCP) of epidermal differentiation complex (EDC) gene in CT of chromosome 1 in squamous cell metaplasia of the uterine cervix.
iv) less condensation of DNA around EDC gene in chromosome 1 of squamous cell metaplasia of the uterine cervix.
From the above results, we concluded that higher-order or angstrom level alteration of chromosomes and DNA architecture could be related to cell morphology through RNA transcription activity change.
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