2010 Fiscal Year Final Research Report
Molecular mechanisms of Hodgkin and anaplastic large cell lymhoma triggered by CD30 induction and P80
| Project/Area Number |
20590374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
HORIE Ryouichi Kitasato University, 医学部, 准教授 (80229228)
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| Co-Investigator(Kenkyū-buntansha) |
IGASHIHARA Masaaki 北里大学, 医学部, 教授 (80165084)
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| Project Period (FY) |
2008 – 2010
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| Keywords | CD30 / JunB / Ets-1 / NPM-ALK / ポジキンリンパ腫 / 未分化大細胞型リンパ腫 |
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| Research Abstract |
Overexpression of CD30 and JunB is a hallmark of tumor cells in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). We report that CD30-ERK-MAPK signaling induces JunB, which maintains constitutive activation of the hypomethylated CD30 promoter. We also localize a cis-acting enhancer in the JunB promoter by Ets-1. We show that Ets-1 enhances JunB promoter activation dependent on CD30 or the NPM-ALK-ERK 1/2 MAPK pathway.
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Research Products
(19 results)
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[Journal Article] CD3- and CD4-positive plasmablastic lymphoma: a literature review of JapanesePlasmablastic, lymphoma cases.2010
Author(s)
Suzuki Y, Yoshida T, Nakamura N, Kamata H, Kotani S, Ohsaka M, Kajita S, Miyazaki K, Ohtani S, Nakayama M, Horie R, Hayakawa K, Niitsu N, Higashihara M.
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Journal Title
Intern Med. 49
Pages: 1801-1805
Peer Reviewed
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[Journal Article] A case of giardiasis expressing severe systemic symptoms and marked, hypereosinophilia.2010
Author(s)
Suzuki Y, Nakamura T, Tokoro M, Togano T, Ohsaka M, Kohri M, Hirata Y, Miyazaki K, Danbara M, Horie R, Miura I, Sunakawa K, Higashihara M.
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Journal Title
Parasitol Int. 59
Pages: 487-489
Peer Reviewed
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[Journal Article] Constitutive activity of nuclear transcription factor kappaB is observed in follicular lymphoma.2010
Author(s)
Suzuki Y, Yoshida T, Horie R, Tsuruta T, Togano T, Ohsaka M, Miyazaki K, Danbara M, Ohtani S, Okayasu I, Higashihara M.
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Journal Title
J Clin Exp Hematop. 50
Pages: 45-50
Peer Reviewed
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[Journal Article] Lymphoproliferative disorders after immunosuppressive therapy for aplastic anemia: a case report and literature review.2009
Author(s)
Suzuki Y, Niitsu N, Hayama M, Katayama T, Ishii R, Osaka M, Miyazaki K, Danbara M, Horie R, Yoshida T, Nakamura N, Higashihara M.
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Journal Title
Acta Haematol. 121
Pages: 21-26
Peer Reviewed
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